2型糖尿病患者摄盐量与糖尿病周围神经病变的相关性
| 作者: |
1朱文博,
1匡洪宇,
1韩爽,
1刘念娇,
1梁苡菲,
1左姣,
1秦文
1 哈尔滨医科大学附属第一医院内分泌科，哈尔滨 150000 |
| 通讯: |
匡洪宇
Email: ydyneifenmier@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.10.020 |
摘要
目的：探究摄盐量(24 h尿钠)与糖尿病周围神经病变(diabetes peripheral neuropathy，DPN)的相关性。方法：选取1 368例中国北方常住2型糖尿病患者为研究对象，通过测量24 h尿钠来评估其摄盐量。采用秩和检验和log i st ic回归分析的方法来研究摄盐量与DPN的关系。结果：24 h尿钠和糖尿病病程是DPN的危险因素(均P<0.05)；舒张压≥80 mmHg和空腹C肽(特指C肽>3.3组)是DPN的保护性因素(OR=0.778，95%CI 0.609~0.993；OR=0.657，95%CI 0.435~0.990)。24 h尿 钠123.84~206.81 mmol和24 h尿钠>206.81 mmol组别罹患DPN的风险分别为24 h尿钠<123.84 mmol组别的1.607倍(OR=1.607，95%CI 1.213~2.129)倍和1.506倍(OR=1.506，95%CI 1.135~1.998)。 结论：摄盐量(24 h尿钠)是DPN的危险因素。
关键词：
2型糖尿病；摄盐量；糖尿病周围神经病变；24 h尿钠
Correlation between salt intake and peripheral neuropathy in patients with type 2 diabetes mellitus
CorrespondingAuthor: KUANG Hongyu Email: ydyneifenmier@163.com
DOI: 10.3978/j.issn.2095-6959.2019.10.020
Abstract
Objective: To explore the correlation between salt intake (24 h urine sodium) and peripheral neuropathy (DPN) of diabetes. Methods: A total of 1 368 type 2 diabetic patients were enrolled into this study. Sodium intake was detected by measuring 24 h urinary sodium. Rank sum test and logistic regression was used to analyze the correlation between salt intake and diabetes peripheral neuropathy. Results: 24 h urinary sodium (salt intake) and duration of diabetes were risk factors for diabetes peripheral neuropathy (P<0.05), and diastolic blood pressure (DBP) ≥80 mmHg and fasting C-peptide (specifically C-peptide >3.3 group) were protective factors for DPN (OR=0.778, 95%CI 0.609–0.993; OR=0.657, 95%CI 0.435–0.990). The risk of diabetes peripheral neuropathy in the group with 24 h urinary sodium 123.84~206.81 mmol and the group with 24 h urinary sodium >206.81 mmol was 1.607 (OR=1.607, 95%CI 1.213–2.129) and 1.506 (OR=1.506, 95%CI 1.135–1.998) times of that in the group with 24 h urinary sodium <123.84 mmol, respectively. Conclusion: Salt intake is a risk factor for peripheral neuropathy in type 2 diabetic patients.
Keywords：
type 2 diabetes mellitus; salt intake; diabetes peripheral neuropathy; 24 h urinary sodium