文章摘要

红细胞分布宽度影响心力衰竭预后的Meta 分析

作者: 1张晓琦, 1姜艳, 1孙远, 1魏晓峰, 2宋耀鸿
1 南京中医药大学研究生院，南京 210023
2 南京中医药大学附属南京中医院心血管病科，南京 210000
通讯: 宋耀鸿 Email: 920653739@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.10.022
基金: 江苏省“六大人才高峰”资助项目 (WSN-067)。

摘要

目的：系统性分析红细胞分布宽度(red cel l d i str i but ion w idth，RDW)对心力衰竭预后价值。方法：利用计算机检索pubmed，embase，web of sc ience三大数据库研究心力衰竭和RDW的相关文献，检索时限为2018年12月5日。危害比(hazard ratio，HR)和95%置信区间(conf idence inter val，CI)作为统计指标。应用Stata12.0计算机软件进行分析，采用Q检验、随机效应模型进行meta分析。结果：共纳入13篇文献，13 311名患者，显示RDW升高，心力衰竭患者预后更差(HR=1.11，95%CI 1.08~1.13，I2=27%，P=0.172)。3篇有关于RDW的变化与急性心力衰竭预后，一共1 294名患者，合并HR=1.17，95%CI 1.08~1.26，I2=0，P=0.393。亚组分析结果提示：高水平RDW的急性心力衰竭患者死亡增高(HR=1.14，95%CI 1.10~1.17，P<0.01)。此外前瞻性研究(HR=1.10，95%CI 1.08~1.13)，近5年发表文献(HR=1.11、95%CI 1.08~1.15)、多因素分析HR值(HR=1.10，95%CI 1.08~1.12)的差异具有统计学意义，异质性不显著。结论：入院时RDW对心力衰竭具有预后价值。
关键词： 红细胞分布宽度；红细胞分布宽度变化；心力衰竭；预后；Meta分析

A Meta-analysis of red cell distribution width in the prognosis of heart failure

Authors: 1ZHANG Xiaoqi, 1JIANG Yan, 1SUN Yuan, 1WEI Xiaofeng, 2SONG Yaohong
1 Graduate School, Nanjing University of Chinese Medicine, Nanjing 210023, China
2 Department of Cardiology, Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, China

CorrespondingAuthor: SONG Yaohong Email: 920653739@qq.com

DOI: 10.3978/j.issn.2095-6959.2019.10.022

Foundation: This work was supported by Jiangsu Province “Six Talents Peak” Subsidized Project, China (WSN-067).

Abstract

Objective: To evaluate the association between red cell distribution width (RDW) and clinical outcome of heart failure patients through a Meta-analysis. Methods: Relevant literatures were retrieved from pubmed, embase and web of science databases until December 5, 2018. Meta-analysis was performed using hazard ratio (HR) and 95% confidence intervals (CIs) as effect measures. Stata 12.0 software was used for analysis, and Q-test and random effect model were used for meta-analysis. Results: A total of 13 311 patients from 13 studies were finally enrolled in the meta-analysis. The summary results showed that elevated RDW predicted poorer mortality of heart failure patients (HR =1.11, 95%CI 1.08–1.13, I2=27%, P=0.172). There were 3 studies about changes in RDW and outcome of acute heart failure, 1 294 patients (HR =1.17, 95%CI 1.08–1.26, I2=0, P=0.393). Subgroup analysis showed that mortality increased in patients with acute heart failure with high RDW level (HR =1.14, 95%CI 1.10–1.17, P<0.01). In addition, rospective studies (HR =1.10, 95%CI 1.08–1.13), papers published in the past 5 years (HR =1.11, 95%CI 1.08–1.15), adjusted HR (HR =1.10, 95%CI 1.08–1.12), the difference is statistically significant, and heterogeneity is not significant. Conclusion: The elevated RDW on admission might be a predicative factor of poor prognosis for heart failure.
Keywords： red cell distribution width; changes in red cell distribution width; heart failure; prognosis; Meta-analysis

文章选项

下载引文

分享