Claudin家族与食管癌发生发展的关系
| 作者: |
1尚晋文,
1白睿华,
2马一杰,
2李宁,
1张成娟
1 郑州大学附属肿瘤医院，河南省肿瘤医院 临床病理中心，郑州 450008 2 郑州大学附属肿瘤医院，河南省肿瘤医院 消化科，郑州 450008 |
| 通讯: |
张成娟
Email: zcj2016@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.10.027 |
摘要
闭合蛋白(Claudin，CLDN)家族是一种上皮细胞间紧密连接的骨架蛋白，其表达异常可引起细胞黏附性减弱、分化程度降低及侵袭性增加。近年来，许多研究表明CLDN与各种恶性肿瘤的发生发展密切相关。CLDN已经被发现在许多肿瘤细胞中表达，不同组织或细胞中的表达具有明显差异性。然而，其在食管癌发生发展中的表达变化及调控机制暂不明确。研究者们进行了大量临床及基础实验，试图对CLDN的异常表达与食管癌的发生发展的关系进行研究，为未来食管癌的治疗特别是探讨转移机制提供新的分子生物学标志物。本文将对CLDN家族在食管癌中的表达、对肿瘤发生发展的影响及其分子机制进行分类阐述。
关键词：
闭合蛋白；食管癌；标记；转移
Relationship of claudin family with the occurrence and development of esophageal cancer
CorrespondingAuthor: ZHANG Chengjuan Email: zcj2016@126.com
DOI: 10.3978/j.issn.2095-6959.2019.10.027
Abstract
Claudin (CLDN) is a kind of cytoskeleton protein which tightly connects epithelial cells, and its abnormal expression can reduce the adhesion of cells, decrease the degree of differentiation and increase the invasiveness. In recent years, many studies show that CLDN is closely related to the development of various malignant tumors. CLDN has been found to be expressed in many tumor cells, with obvious differences in expression between different tissues or cells. However, the changes in CLDN expression and mechanisms of regulation in esophageal cancer are not clear yet. and Researchers have conducted a large number of clinical and basic experiments to try to study the relationship between abnormal expression of CLDN and the occurrence and development of esophageal cancer, so as to provide new molecular markers for future treatment of esophageal cancer, especially to explore the metastasis mechanism. In this paper, the expression of CLDN family in esophageal cancer, its influence on tumorigenesis and development, and its molecular mechanism were classified.
Keywords：
Claudin; esophageal cancer; marker; metastasis