Peroxiredoxin-6活性调控及其与疾病发生的关系
| 作者: |
1杨海玉
1 江西省人民医院临床医学研究所，南昌 330006 |
| 通讯: |
杨海玉
Email: 363042946@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.09.035 |
| 基金: | 国家自然科学基金(81760038)；江西省卫生和计划生育委员会科技计划(20161014)。 |
摘要
Peroxiredoxin(Prdx)是新发现的抗氧化酶蛋白家族，包括6个亚型。与其他亚型不同的是，Peroxiredoxin-6(Prdx6)具有独特的结构且可表现多种功能活性。Prdx6仅含有一个保守的半胱氨酸残基(cysteine residue，Cys)，并表现3种活性：过氧化酶活性、磷脂酶A2活性(phospholipase A2 activity，PLA2)和溶血卵磷脂酰基转移酶(lysolecithin acyltransferase，LPCAT)活性。研究认为Prdx6的活性调控受到亚细胞定位、底物结合及翻译后修饰等因素影响。目前研究证实Prdx6与一些疾病发生密切相关，包括肿瘤、炎性疾病、缺血性脑卒中、创伤性脑损伤及神经退行性病变等。深入阐明Prdx6与这些疾病的关系可为其治疗提供新的靶点和方向。
关键词：
peroxiredoxin-6；氧化应激；肿瘤；炎症；神经退行性病变
Regulation of Peroxiredoxin-6 activity and its relationship with diseases
CorrespondingAuthor: YANG Haiyu Email: 363042946@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.09.035
Foundation: This work was supported by the National Natural Science Foundation (81760038) and Project from Health and Family Planning Commission of Jiangxi Province (20161014), China.
Abstract
Peroxiredoxin (Prdx) is a new family of antioxidant enzyme, including six subtypes. Unlike other subtypes, Prdx6 has unique structure and expresses various activities. Prdx6 contains only a conservative cysteine residue (Cys), and has three kinds of activities, including peroxidase activity, phospholipase A2 activity (PLA2) and lysolecithin acyltransferase (LPCAT) activity. Research has indicated that Prdx6 activities are regulated by its subcellular localization, the combination of substrate, as well as its modification after translation. Recently, study has confirmed that Prdx6 is closely associated with the pathogenesis of some diseases, such as cancer, inflammatory diseases, ischemic stroke, traumatic brain injury and neural degenerative diseases. Further clarifying the role of Prdx6 in the pathogenesis of these diseases may provide a new therapeutic target and research direction.
Keywords：
peroxiredoxin-6; oxidative stress; tumor; inflammation; neural degenerative disease