Objective: To analyze the effect of laparoscopic radical resection on risk of metastatic for colon cancer and epidermal growth factor (EGF) level and clinical outcomes of colon cancer. Methods: From April 2013 to November 2015, 112 patients with colon cancer were retrospectively divided into two groups: a control group and an observation group, 56 cases in each group. Laparotomy was performed in the open group and laparoscopic radical resection of colon cancer was performed in the endoscopic group. The operation, complications, tumor recurrence, metastasis, metastatic potential and EGF level were analyzed in the two groups. Results: The operative time of the endoscopic group was longer than that of the open group (P<0.001), the recovery time of gastrointestinal function was shorter than that of the open group (P<0.001), the amount of intraoperative bleeding was less than that of the open group (P<0.001), and the complication rate was lower than that of the open group (P=0.015), but there was no significant difference in local recurrence rate and distant metastasis between the 2 groups (P=0.647, 0.280). There was no significant difference in TK1, EGF, SAA, IL-8, IL-17 levels between the two groups before operation (all P>0.05). After operation, the level of TK1, EGF, SAA, IL-8, IL-17 in the endoscopic group was lower than that in the open group (all P<0.05). There was no significant difference in the expression of GCC-mRNA between the two groups before operation (P=0.848). After operation, the positive rate of GCC-mRNA expression in peripheral blood of endoscopic group was higher than that of open group, but there was no statistical difference between the two groups (P=0.411). Conclusion: Laparoscopic radical resection of colon cancer can reduce bleeding in hands, shorten the recovery time after operation, and reduce the expression of TK1, EGF, SAA and IL-8 in serum of patients with colon cancer, with fewer complications and high safety, but the metastatic potential of tumors is similar to that of the open group.