雌激素相关受体α在肿瘤中的研究进展
| 作者: |
1李萍,
1,2袁建辉,
1吴雯,
1,3谢妮
1 南华大学，湖南 衡阳 421001 2 深圳市南山区疾病预防控制中心，广东 深圳 518054 3 深圳市第二人民医院生物样本库，广东 深圳 518035 |
| 通讯: |
谢妮
Email: xn100@szu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2019.08.028 |
| 基金: | 广东省自然科学基金(2017A030313668)；深圳市科技创新委员会项目(JCYJ20160328161613864，JSGG20170414104216477)。 |
摘要
孤儿核受体雌激素相关受体α(estrogen-related receptor α，ERRα)是核受体超家族(nuclear receptor superfamily，NRs)中无需和配体结合便可发挥其生物学功能的特殊类型。早期对ERRα的研究主要侧重于其参与和影响雌激素信号转导途径，以及其对机体正常能量代谢的调控研究。近年来，研究发现ERRα能在肿瘤发生和发展进程中调控肿瘤细胞的代谢重编程来满足其能量需求。ERRα在肿瘤领域受到广泛的关注还表现在其用于靶向治疗的成药潜力，以及对肿瘤患者不良预后的评估作用等方面。
关键词：
孤儿核受体；雌激素相关受体α；肿瘤；治疗；预后
Research progress of estrogen-related receptor α in cancer
CorrespondingAuthor: XIE Ni Email: xn100@szu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2019.08.028
Foundation: This work was supported by the Natural Science Foundation of Guangdong (2017A030313668) and Project of Shenzhen Science and Technology Innovation Committee (JCYJ20160328161613864, JSGG20170414104216477)
Abstract
Orphan nuclear receptor ERRα (estrogen-related receptor α, ERRα) is a special type of the nuclear receptor superfamily that can exert the biological function without binding to the ligand. Early studies on ERRα are aimed at its effects on estrogen signaling pathways and regulation of normal energy metabolism in vivo. In recent years, ERRα is found to regulate the metabolic reprogramming of tumor cells in the process of tumorigenesis and development to meet its energy requirements. The orphan nuclear receptor ERRα has received extensive attention in the field of tumors. Numerous studies have shown that ERRα is closely related to the occurrence and development in many cancers, and its druggable potential in targeted therapy and evaluation of poor prognosis are also shown in cancer patients.
Keywords：
orphan nuclear receptor; estrogen-related receptor alpha; cancer; therapy; prognosis