Objective: To explore the effect of praecox sodium on knee joint function and serum inflammatory response in patients with knee osteoarthritis undergoing total knee arthroplasty. Methods: Eighty cases of total knee arthroplasty treated with total knee arthroplasty in Langfang Fourth People’s Hospital from September 2015 to February 2017 were divided into a control group and a super front pain group, with 40 cases in each group. The preemptive analgesia group were injected parecoxib sodium 30 min before anesthesia induction. The control group did not use any analgesia before operation. The Visual Analogue Scale (VAS) pain score, hospital for special surgery knee score and serum inflammatory factors in two groups were compared in patients before and after 24 h operation. Results: Before operation, there was no significant difference in the visual analogue score of the two groups (P>0.05); and the VAS score of the group after the operation was lower than that of the control group (24 h), and the difference was statistically significant (P<0.05). Before operation, the difference of hospital for special surgery (HSS) score between the two groups was not statistically significant (P>0.05). The HSS score of the group after the operation was higher than that of the control group, and the difference was statistically significant (P<0.05). Before operation, there was no significant difference in serum inflammatory factors IL-6, TNF-α and CRP (P>0.05) in the two groups of patients, and 24 h, IL-6, TNF-α and CRP in the postoperatively group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: Preoperative analgesia with parecoxib sodium in patients undergoing total knee arthroplasty for knee osteoarthritis can achieve postoperative analgesia, reduce postoperative pain VAS score, and improve knee function of patients. Reducing the level of serum inflammatory factors in the perioperative period of knee arthroplasty is worthy of clinical use.