溃疡性结肠炎患者骨密度变化及其影响因素
| 作者: |
1施慧,
1康颖,
2杨路昕,
1魏娟,
1王慧,
1陈春燕,
1杨妙芳,
1汪芳裕,
1陶慧
1 东部战区总医院(原南京军区南京总医院)消化内科，南京 210000 2 东部战区总医院(原南京军区南京总医院)中西医结合科，南京 210000 |
| 通讯: |
汪芳裕
Email: wangfy65@nju.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2019.07.016 |
| 基金: | 国家自然科学基金 (81570506)。 |
摘要
目的：研究溃疡性结肠炎(ulcerative colitis，UC)患者的骨密度变化并分析其相关的影响因素。方法：回顾性分析正常对照组(n=30)及UC患者(n=50)的临床资料，测定两组的骨密度并进行对比，记录UC组性别、年龄、体重指数(BMI)、病程、病变累及范围、激素使用史、免疫抑制剂使用史等7个因素，对影响因素进行统计学分析。结果：UC组患者的双股骨骨密度、双股骨T值较正常对照组明显较低，差异有统计学意义(P<0.05)；UC组骨密度减低及骨质疏松发生率均高于正常对照组；BMI和左半结肠受累的UC可联合预测L1~L4骨密度降低20.9%的变异量；免疫抑制剂使用史、BMI和左半结肠受累可联合预测双侧股骨颈骨密度降低的34%的变异量。结论：UC患者骨密度减低，骨质疏松发生率升高。免疫抑制剂使用史、BMI和左半结肠受累是影响骨密度的主要因素。
关键词：
溃疡性结肠炎；骨密度；骨量减少；骨质疏松；体重指数
Bone mineral density and its risk factors in ulcerative colitis patients
CorrespondingAuthor: WANG Fangyu Email: wangfy65@nju.edu.cn
DOI: 10.3978/j.issn.2095-6959.2019.07.016
Foundation: This work was supported by National Natural Science Foundation of China (81570506).
Abstract
Objective: To investigate bone mineral density (BMD) in ulcerative colitis (UC) patients and to identify the risk factors of osteopenia and osteoporosis. Methods: Fifty UC patients and 30 healthy controls were enrolled retrospectively. The BMD was determined by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and the femoral neck. BMD were determined and compared. The patient gender, age, BMI, history, bowel involvement, disease activity and treatment were recorded and analyzed. Results: BMD of the femoral neck, T score of the femoral in UC patients were lower than the control group (P<0.05). The rate of osteopenia and osteoporosis in UC patients were higher than the control group. BMI and UC involved in the left colitis could predict the variation of 20.9% in BMD of L1-L4, while immunosuppressive agents use, BMI and left colitis could predict the decrease of BMD in femoral. Conclusion: The osteoporosis in UC patients is low and the rate of osteopenia increases. Immunosuppressive agents use, BMI and left colitis were the main risk factors of BMD in UC patients.
Keywords：
ulcerative colitis; bone mineral density; osteopenia; osteoporosis; body mass index