狼疮性肾炎凝血异常的研究进展
| 作者: |
1侯丽,
1解汝娟
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150001 |
| 通讯: |
解汝娟
Email: xierujuan111@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.07.035 |
| 基金: | 国家自然科学基金 (81470301)。 |
摘要
狼疮性肾炎(lupus nephritis，LN)是具有高凝状态的疾病，是增加动静脉血栓的独立危险因素。目前认为免疫复合物的沉积是导致LN患者肾损伤的直接原因，但继发的血栓可能是导致肾损伤和肾功不全的另一重要因素。然而，LN疾病高凝状态的机制并不明确。全面理解该疾病的血栓发生机制，并提供有效的治疗措施，可以延缓肾纤维化及肾功能不全的进程。
关键词：
狼疮性肾炎；凝血功能异常；高凝状态
Research on the coagulopathy of lupus nephritis
CorrespondingAuthor: XIE Rujuan Email: xierujuan111@163.com
DOI: 10.3978/j.issn.2095-6959.2019.07.035
Foundation: This work was supported by the National Natural Science Foundation of China (81470301).
Abstract
Lupus nephritis (LN) is associated with a hypercoagulable state and an increased risk for venous and arterial thrombosis. Although immune complexes are thought to produce most forms of injury in LN, thromboembolic complications may be another important cause of renal injury and kidney dysfunction. However, the mechanisms specific to LN that promote a hypercoagulable state have not been identified. Understanding the development of the thrombosis in LN and providing possible treatment options for the hypercoagulable state in this disease could delay the process of renal fibrosis and renal failure.
Keywords：
lupus nephritis; coagulopathy; hypercoagulable state