内皮祖细胞与糖尿病血管再生障碍的研究进展
| 作者: |
1郭梓,
1莫朝晖
1 中南大学湘雅三医院内分泌科，长沙 410013 |
| 通讯: |
莫朝晖
Email: easd04mzh@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.07.028 |
| 基金: | 国家自然科学基金 (81670769)。 |
摘要
糖尿病内皮功能障碍和新生血管受损，与糖尿病心血管并发症发生密切相关。内皮祖细胞(endothelial progenitor cells，EPCs)是一类骨髓来源的细胞，其在机体受损后的内皮化过程和血管修复中发挥重要作用，不仅可以将自身整合到新形成的毛细血管中，还可以旁分泌促血管生成因子发挥作用。糖尿病患者EPCs数目减少、功能受损与外周动脉粥样硬化之间联系紧密，对糖尿病大血管病变的严重程度具有指示作用，改善EPCs的功能可以促进糖尿病下肢缺血模型的血流恢复。因此，EPCs有望成为糖尿病大血管病变的治疗靶点。
关键词：
糖尿病大血管病变；内皮祖细胞；内皮克隆形成细胞；血管新生
Research progress of endothelial progenitor cells and impaired angiogenesis in diabetes
CorrespondingAuthor: MO Zhaohui Email: easd04mzh@126.com
DOI: 10.3978/j.issn.2095-6959.2019.07.028
Foundation: This work was supported by the National Natural Science Foundation of China (81670769).
Abstract
Diabetic endothelial dysfunction and impaired angiogenesis are closely related to the occurrence of diabetic cardiovascular complications. Endothelial progenitor cells (EPCs) are bone marrow-derived cells that play an important role in endothelialization and vascular repair after injury. They can promote vascularization either by incorporation into nascent blood vessels or by the paracrine production of angiogenic factors. The decreased number and impaired function of diabetic EPCs are closely connected with peripheral atherosclerosis, indicating the severity of diabetic macroangiopathy. Blood flow recovery can be promoted by improving the function of EPCs in diabetic ischemia models. Thus, EPCs might be a potential therapeutic target for diabetic macroangiopathy.
Keywords：
diabetic macroangiopathy; endothelial progenitor cells; endothelial colony forming cells; angiogenesis