FGF23在慢性肾脏病中的研究进展
| 作者: |
1蔡明,
1王兴智
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150000 |
| 通讯: |
王兴智
Email: Wang.xingzhi@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.06.029 |
| 基金: | 黑龙江省教育厅海外学人科研资助项目 (1253HQ006)。 |
摘要
慢性肾病(chronic kidney disease，CKD)已经成为全球性的健康问题。CKD患者几乎都存在着不同程度的钙磷代谢紊乱、贫血等问题，对患者生活质量和预后造成严重影响。成纤维生长因子(fibroblast growth factor 23，FGF23)是近年来的研究热点，其在骨矿物质代谢、贫血等方面发挥重要调节作用。FGF23可通过多种途径调节血磷，血清FGF23浓度与贫血存在相关性。
关键词：
慢性肾脏病；成纤维生长因子；促红细胞生成素；贫血
Research progress in FGF23 in chronic kidney disease
CorrespondingAuthor: WANG Xingzhi Email: Wang.xingzhi@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2019.06.029
Foundation: This work was supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Heilongjiang Education Committee, China (1253HQ006).
Abstract
Chronic kidney disease (CKD) has become a global health problem. CKD patients almost all have different levels of calcium and phosphorus metabolism disorders, anemia and other issues, which have a serious impact on patients' quality of life and prognosis. Fibroblast growth factor 23 (FGF23) is a research hotspot in recent years, which plays an important regulatory role in bone mineral metabolism and anemia. FGF23 can regulate blood phosphorus in a variety of ways, and serum FGF23 concentration is associated with anemia.
Keywords：
chronic kidney disease; fibroblast growth factor 23; erythropoietin; anemia