心脏标志物在慢性肾脏病患者中的临床应用及研究进展
| 作者: |
1孟杰,
1王姝,
1王岚峰
1 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150001 |
| 通讯: |
王岚峰
Email: lanfengwang@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.06.030 |
| 基金: | 国家自然科学基金 (81401151)。 |
摘要
心血管疾病(cardiovascular disease，CVD)是慢性肾脏病(chronic kidney disease，CKD)患者发病和死亡的主要原因。因此，早发现、早诊断并积极治疗十分重要。CVD的诊断是一个综合诊断，最常用的辅助检查是心脏标志物，如心肌肌钙蛋白(cTn)、脑利钠肽、超敏C反应蛋白(hypersensitive C-reactive protein，hs-CRP)、可溶性生长刺激表达基因2蛋白(soluble suppression of tumorigenicity 2，sST2)等。但由于受肾功能影响，这些标志物的参考值有所变化，在CKD患者中，心脏标志物值的变化在临床应用中的意义仍需进一步探索。
关键词：
心脏标志物；慢性肾脏病；临床应用
Clinical application and research progress in cardiac markers in patients with chronic kidney disease
CorrespondingAuthor: WANG Lanfeng Email: lanfengwang@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2019.06.030
Foundation: This work was supported by the National Natural Science Foundation of China (81401151).
Abstract
Cardiovascular disease (CVD) is the main cause of morbidity and mortality among patients with chronic kidney disease (CKD). Therefore, it is important to early detection, diagnosis and treatment in patients with CKD. The diagnosis of CVD is comprehensive, and cardiac biomarkers are crucial, such as cardiac troponin, brain natriuretic peptide, hypersensitive C-reactive protein, soluble growth stimulation-expressed gene 2 protein, etc. However, the reference value of these markers changes due to the influence of renal function, and the significance of the changes in cardiac markers in the clinical application of CKD patients still needs to be further explored.
Keywords：
cardiac markers; chronic kidney disease; clinical application