文章摘要

糖尿病性视网膜病中血-视网膜屏障损伤的研究进展

作者: 1贺鹏程, 2刘昌汶, 3尹卫东, 4石金凤
1 南华大学研究生院，湖南 衡阳 421001
2 南华大学衡阳医学院医学影像学专业，湖南 衡阳 421001
3 南华大学衡阳医学院生物系，湖南 衡阳 421001
4 南华大学衡阳医学院应用解剖与生殖医学研究所，湖南 衡阳 421001
通讯: 尹卫东 Email: wdy20042004@126.com
DOI: 10.3978/j.issn.2095-6959.2019.05.029
基金: 湖南省自然科学基金 (14JJ2084)；南华大学大学生研究性学习和创新性试验计划 (2017XJXZ037)。

摘要

糖尿病视网膜病(diabetic retinopathy，DR)病理过程与血-视网膜屏障(blood-retinal barrier，BRB)损伤密切相关，BRB损伤和渗透性增加，导致黄斑水肿，是2型糖尿病患者视力丢失的主要原因。 BRB主要包括内屏障(iBRB)和外屏障(oBRB)，其功能及生理作用不同，对环境刺激的敏感性也 不同。
关键词： 糖尿病视网膜病；血-视网膜屏障；血管内皮生长因子；糖尿病黄斑水肿

Research progress of blood-retinal barrier injure in diabetic retinopathy

Authors: 1HE Pengcheng, 2LIU Changwen, 3YIN Weidong, 4SHI Jinfeng
1 Graduate School, University of South China, Hengyang Hunan 421001, China
2 Major of Medical Imaging, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China
3 Department of Biology, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China
4 Institute of Applied Anatomy and Reproductive Medicine, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: YIN Weidong Email: wdy20042004@126.com

DOI: 10.3978/j.issn.2095-6959.2019.05.029

Foundation: This work was supported by Hunan Provincial Natural Science Foundation (14JJ2084) and Student Research Learning and Innovative Pilot Project of University of South China (2017XJXZ037), China.

Abstract

The pathological process of diabetic retinopathy (DR) is closely related to the damage to blood-retinal barrier (BRB). The increase of BRB damages and permeability lead to macular edema, which is the main cause of visual loss in type 2 diabetic patients. BRB mainly includes inner barrier and outer barrier, which have physiological functions, and have different sensitivities to environmental stimuli.
Keywords： diabetic retinopathy; blood-retinal barrier; vascular endothelial growth factor; diabetic macular edema

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