内皮素及其受体与缺血性心脏病
| 作者: |
1陈娟,
1何东,
1胡佳,
1韦星
1 南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，湖南 衡阳 421001 |
| 通讯: |
韦星
Email: weixing22@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.05.032 |
摘要
内皮素(endothelin，ET)是内皮细胞中分离出的一种活性多肽，是迄今所知最强的缩血管物质之一。它不仅存在于血管内皮细胞中，也广泛存在于心脏、大脑、肺和胃肠道系统中，是调节心血管功能的重要因子，并对缺血性心脏病的发生、发展起非常重要的作用。本文对ET及其相关受体的产生及水平，在心脏缺血性病变如缺血-再灌注损伤(ischemia/reperfusion injur y，I/R)、心肌无复流、室性心率失常等中的作用作一综述。
关键词：
内皮素；缺血-再灌注损伤；心肌无复流；室性心律失常
Endothelin and its receptors and ischaemic heart disease
CorrespondingAuthor: WEI Xing Email: weixing22@163.com
DOI: 10.3978/j.issn.2095-6959.2019.05.032
Abstract
Endothelin is an active polypeptide isolated from endothelial cells and the strongest vasoconstrictor known to date. It not only exists in vascular endothelial cells, but also widely exists in the heart, brain, lung and gastrointestinal system. It is one of the most important factors regulating cardiovascular function, and plays a very important role in the occurrence and development of ischemic heart disease. This article reviews the production and level of endothelin and its related receptors in ischemic heart disease, such as ischemia-reperfusion injury, no-reflow, ventricular arrhythmia and so on, and looks forward to its application prospects.
Keywords：
endothelin; ischemia-reperfusion injury; myocardial no-reflow; ventricular arrhythmia