血清YKL-40 水平与多肌炎/ 皮肌炎的相关性
| 作者: |
1陈尚周,
1周发琼
1 恩施土家族苗族自治州中心医院皮肤科，湖北 恩施 445000 |
| 通讯: |
周发琼
Email: zhoufaqiongpifu@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.05.006 |
摘要
目的：探究血清YKL-40水平与多肌炎/皮肌炎(polymyositis/dermatomyositis，PM/DM)的相关性。方法：纳入99例确诊为PM/DM患者和87例健康者(对照组)。ELISA检测血清YKL-40水平，记录患者临床相关指标。以肌病活动性视觉模拟评分评估疾病的活动性，以发生间质性肺病(interstitial lung disease，ILD)评估疾病的严重程度。结果：PM/DM患者血清YKL -40水平显著高于对照组，差异有统计学意义。血清YKL -40水平与视觉模拟评分( r=0.65，P<0.01)、C反应蛋白(r=0.33， P<0.01)、红细胞沉降率(r=0.65，P<0.01)、铁蛋白(r=0.62，P<0.01)呈正相关。PM/DM患者中合并ILD患者血清YKL-40水平显著高于非ILD患者，差异有统计学意义。YKL-40可用于评估ILD的诊断(ROC曲线下面积为0.82，P<0.01)。结论：血清YKL-40水平可用于评估PM/DM的疾病活动性和严重程度。
关键词：
多肌炎；皮肌炎；YKL-40；相关性
Correlation between serum YKL-40 and polymyositis/dermatomyositis
CorrespondingAuthor: ZHOU Faqiong Email: zhoufaqiongpifu@163.com
DOI: 10.3978/j.issn.2095-6959.2019.05.006
Abstract
Objective: To investigate the correlation between serum YKL-40 and polymyositis/dermatomyositis (PM/DM). Methods: A total of 99 patients with definite PM/DM were prospectively enrolled. 87 healthy individuals were set as a control. Serum YKL-40 levels were determined using ELISA. The clinical characteristics of PM/DM were recorded. Disease activity of PM/DM was estimated using myositis disease activity assessment visual analogue scale. Disease severity was estimated by the occurrence of interstitial lung disease (ILD). Results: The patients with PM/DM had significantly higher serum YKL-40 concentrations than the healthy controls. Serum YKL-40 levels were positively correlated with myositis disease activity assessment visual analogue scale (r=0.65, P<0.01), C-reactive protein (r=0.65, P<0.01), erythrocyte sedimentation rate (r=0.65, P<0.01) and ferritin (r=0.65, P<0.01). Patients with ILD had significantly higher YKL-40 concentrations than those without. The area under receiver operating characteristic curve of YKL-40 for identifying ILD was 0.87 (P<0.01). Conclusion: Serum YKL-40 is a useful biomarker for estimating disease activity or severity of PM/DM.
Keywords：
polymyositis; dermatomyositis; YKL-40; correlation