细胞周期调控系统Cyclins-CDKs-CKIs在创面愈合中作用的研究进展
| 作者: |
1,2,3罗月,
1,2,3蒯仂,
1,2,3茹意,
1,2吴人杰,
1,2,3李欣,
1,2,3李斌
1 上海中医药大学岳阳临床医学院，上海 201203 2 上海中医药大学附属岳阳中西医结合医院皮肤科， 上海 200437 3 上海市中医药研究院皮肤病研究所，上海 201203 |
| 通讯: |
李斌
Email: 18930568129@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.034 |
| 基金: | 国家自然科学基金 (81273764，81302971，81473682，81673866)；国家重点研发计划“中医药现代化研究”重点专项 (SQ2018YFC170043)；上海市科学技术委员会项目 (16QA1403800)；上海市卫生与计划生育委员会中医药事业发展三年行动计划 (ZY3-CCCX-1-1008，ZY3-CCCX-3-3033)；上海市卫生与计划生育委员会中医药科研基金 (2014LQ103A)；上海申康医院发展中心项目 (16CR2035B)；上海中医药大学第十批大学生科技创新项目 ( JX61.08.97，JX61.08.98)；研究生创新培养项目 (Y201850)。 |
摘要
细胞周期调控系统相关因子调控细胞周期进展，在创面愈合炎症期与修复期均发挥重要作用。细胞周期蛋白(Cyclin)通过Cyclin依赖性激酶(Cyclin-dependent kinases，CDKs)调控细胞周期，而CDKs的抑制剂(Cyclin-dependent kinase inhibitor，CKI)具有抗炎作用，在炎症期抑制cyclinD1基因的表达可能通过防止巨噬细胞过度增殖，从而消退炎症反应，利于慢性创面的愈合；在创面修复期下调细胞周期正向调控因子CyclinD，CyclinE1，上调细胞周期负向调控因子p21cip1，p27kip1等的表达可抑制成纤维细胞的异常增殖从而减少瘢痕增生。Cyclins-CDKs-CKIs的潜在治疗价值是消退炎症反应，促进创面愈合，并抑制瘢痕增生，深入了解其在创面愈合不同阶段中的作用，对探索促进创面愈合、抑制瘢痕增生的治疗靶点具有重要意义。
关键词：
Cyclins-CDKs-CKIs；炎症；瘢痕增生；创面愈合
Research progress in roll of cell cycle regulation system Cyclins-CDKs-CKIs in wound healing
CorrespondingAuthor: LI Bin Email: 18930568129@163.com
DOI: 10.3978/j.issn.2095-6959.2019.04.034
Foundation: This work was supported by the National Natural Science Foundation (81273764, 81302971
Abstract
Cell cycle regulation system-related factors regulate cell cycle progression, and have important expression significance in wound healing and repair phase. Cyclin regulates cell cycle through cyclin-dependent kinases (CDKs), and inhibitors of CDKs have anti-inflammatory effects. Inhibition of CyclinD1 gene expression during inflammatory phase can prevent hyper proliferation of macrophages, thereby may attenuating inflammatory response and facilitating healing of chronic wounds; Down-regulation of cell cycle positive regulators CyclinD, CyclinE1, upregulation of cell cycle negative regulatory factors p21cip1, p27kip1 can inhibit the abnormal proliferation of fibroblasts and reduce scar hyperplasia. The potential therapeutic value of Cyclins-CDKs-CKIs is to attenuate the inflammatory response to promote wound healing and reduce scar hyperplasia, and to understand its role in different stages of wound healing. It is of great significance for exploring therapeutic targets for promoting wound healing and inhibiting the development of hypertrophic scars.
Keywords：
Cyclins-CDKs-CKIs; inflammation; hypertrophic scar; wound healing