慢性炎症与肥胖型高血压关联机制的研究进展
| 作者: |
1张德慧,
1李满,
1余佳
1 武汉大学人民医院肝胆外科，武汉 430000 |
| 通讯: |
余佳
Email: hbpennhmp116@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.031 |
| 基金: | 中国留学基金委 [ 留金发 (2017)3059 号 ]；2016 武汉市中青年医学骨干人才项目 [ 武卫生计生 (2016)59 号 ]。 |
摘要
肥胖诱发高血压是一个缓慢的过程，其发病机制迄今尚未完全明确。但肥胖本身作为一种全身低水平慢性持续性炎症状态，慢性炎症在肥胖型高血压中发挥重要作用。肥胖型高血压的病理生理学机制可归纳为脂肪组织病变，肾素–血管紧张素–醛固酮系统激活，交感神经系统激活，胰岛素抵抗，血管功能异常与肾脏病变，上述机制的本质均为炎症反应的结果。
关键词：
慢性炎症；肥胖；高血压
Research progress in the mechanism of association between chronic inflammation and obesity hypertension
CorrespondingAuthor: YU Jia Email: hbpennhmp116@163.com
DOI: 10.3978/j.issn.2095-6959.2019.04.031
Foundation: This work was supported by the China Scholarship Council [CSC(2017)3059] and 2016 Wuhan Young and Middle-aged Medical Backbone Talent Training Project [Wuhan Municipal Commission of Health and Family Planning (2016) 59], China.
Abstract
Obesity-induced hypertension is a slow process, and its mechanism is not yet clear up till now. Meanwhile, obesity itself is a low-level chronic persistent inflammatory state in the whole body which indicates that chronic inflammation plays an important role in obesity hypertension. The pathophysiological mechanisms of obesity hypertension can be summed up as adipose tissue lesions, renin-angiotensin-aldosterone system activation, sympathetic nervous system activation, insulin resistance, vascular dysfunction and renal lesions. They are essentially caused by inflammation.
Keywords：
chronic inflammation; obesity; hypertension