脂蛋白相关磷脂酶A2及其与糖尿病视网膜病变相关性的进展
| 作者: |
1李婷婷,
1谢晓竞
1 南京医科大学附属南京医院，南京市第一医院内分泌科，南京 210006 |
| 通讯: |
谢晓竞
Email: xxjnanjing@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.030 |
摘要
糖尿病视网膜病变(diabetic retinopathy，DR)是导致不可逆性眼盲的重要原因之一，DR发病与动脉粥样硬化密切相关，其治疗干预靶点成为当今研究的热点。脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2，Lp-PLA2)是一种新型炎症因子，与动脉粥样硬化及炎症反应等相关。了解Lp-PLA2与DR相关性研究现状可能为进一步研究DR治疗提供新的思路。
关键词：
糖尿病视网膜病变；脂蛋白相关磷脂酶A2；动脉粥样硬化；血脂
Progress in lipoprotein-associated phospholipase A2 and its correlation with diabetic retinopathy
CorrespondingAuthor: XIE Xiaojing Email: xxjnanjing@sina.com
DOI: 10.3978/j.issn.2095-6959.2019.04.030
Abstract
Diabetic retinopathy (DR) is one of the important causes of irreversible blindness. DR is closely related to atherosclerosis, and its therapeutic intervention target has become a hot topic in current research. Lipoprotein-associated phospholipase A2 (Lp-PLA2), as a new inflammation factor, is related to atherosclerosis and inflammatory response. Understanding the current correlation of Lp-PLA2 and DR may provide a novel option in future treatment of DR.
Keywords：
diabetic retinopathy; lipoprotein-associated phospholipase A2; atherosclerosis; lipid