Betatrophin 在非酒精性脂肪性肝病发病中的研究进展
| 作者: |
1廖哲珍,
1王亚荻
1 南华大学附属第一医院内分泌代谢科，湖南 衡阳 421001 |
| 通讯: |
王亚荻
Email: yadingusc@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.029 |
| 基金: | 国家自然科学基金 (81870595)；湖南省卫生和计划生育委员会重大专项 (A2017011)。 |
摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease，NAFLD)是肝功能障碍最常见的原因之一，与肥胖和代谢紊乱高度相关。然而肝脂肪变性的发病机制十分复杂，尤其是肝细胞和肝细胞因子之间的相互作用尚未完全阐明。促代谢因子或者血管紧张素蛋白8(又称Betatrophin)作为新型的肝细胞因子，其通过调节三酰甘油(TG)代谢、胰岛素抵抗(insulin resistance，IR)和炎症，参与NAFLD的形成。
关键词：
非酒精性脂肪性肝病；Betatrophin；肝细胞因子
Novel insights into the betatrophin in pathogenesis of non-alcoholic fatty liver disease
CorrespondingAuthor: WANG Yadi Email: yadingusc@163.com
DOI: 10.3978/j.issn.2095-6959.2019.04.029
Foundation: This work was supported by the National Natural Science Foundation (81870595) and Major Special Projects of Hunan Provincial Health and Family Planning Commission (A2017011), China.
Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent causes of hepatic dysfunction and is highly correlated with obesity and metabolic disturbance. The complex pathogenesis of NAFLD, especially the interaction between hepatocytes and hepatokines has not been fully elucidated. Betatrophin, as a novel hepatokines, are likely to be involved in the pathogenesis of NAFLD via modulating triglyceride metabolism, insulin resistance and inflammation.
Keywords：
non-alcoholic fatty liver disease; betatrophin; hepatokines