Objective: To study the effects of nursing intervention regimen based on prevention of incontinence-associated dermatitis (IAD) in patients with fecal incontinence in intensive care unit (ICU). Methods: A total of 104 patients with fecal incontinence admitted to the ICU from May 2016 to May 2018 were selected and randomly divided into an observation group and a control group (52 cases in each group). The control group was given routine nursing, and the observation group was given nursing intervention regimen based on prevention of IAD. The incidence rate, occurrence time, score and nursing time of IAD during nursing, the damage degree of perianal skin maceration and stages of pressure sores during nursing intervention, and stool management effects and damage healing after nursing intervention were observed in the two groups. Results: The incidence rate of IAD in observation group was lower than that in control group (7.69% vs 25.00%) (P<0.05). The occurrence time in observation group was significantly higher than that in control group (P<0.05), and the IADS scale score and nursing time in observation group were significantly lower than those in control group (P<0.05). The damage degree of perioral skin maceration and stages of pressure sores during nursing in observation group were lower than those in control group (P<0.05). The effects of stool management after nursing intervention in observation group were better than those in control group (P<0.05). The effective rate of skin healing in observation group was significantly higher than that in control group (100.00% vs 57.89%) (P<0.05). Conclusion: Nursing intervention regimen based on prevention of IAD for ICU patients with fecal incontinence can reduce the incidence rate of IAD, prolong the occurrence time of IAD, reduce the damage degree of perioral skin maceration and stages of pressure sores, and improve stool management effects and skin healing.