Objective: To investigate the effect of 1% tetracaine hydrochloride spray combined with external application of traditional Chinese medicine in patients with acute skin bruises. Methods: A total of 168 cases of acute skin bruises were randomly divided into control group, observation group A and observation group B, 56 cases in each group. The control group was treated with routine debridement. The observation group A was treated with routine debridement combined with external application of traditional Chinese medicine. The observation group B was treated with external application of 1% tetracaine hydrochloride. The Visual Analogue Scale (VAS) score, wound infection rate, wound healing time, and adverse reactions during debridement and the first dressing change were compared among the 3 groups. Results: No wound infection, local allergy and systemic reaction occurred in all the three groups. The VAS score during debridement and the first dressing change and wound healing time were significantly different among the 3 groups (P<0.05). Further comparisons between groups showed that there was no significant difference in VAS score between the control group and the observation group A (P>0.05), and both were significantly higher than the observation group B (P<0.05). There was significant difference in VAS score between groups at the first dressing change (control group > observation group A > observation group B, P<0.05). There was no significant difference in wound healing time between group A and group B (P>0.05), and both were significantly lower than the control group (P<0.05). Conclusion: 1% tetracaine hydrochloride spray can effectively control the pain of acute skin contusion patients during debridement and dressing change after operation. Combination of external application of traditional Chinese medicine can promote wound healing and is worthy of further promotion in clinical practice.