血清胆红素水平与大动脉炎之间的相关性
| 作者: |
1张复贵,
2陈龙菊,
1雷玉华
1 恩施州中心医院内科心血管病中心，湖北 恩施 445000 2 湖北民族大学医学院解剖教研室，湖北 恩施 445000 |
| 通讯: |
雷玉华
Email: huayulei_0319@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.019 |
| 基金: | 国家自然科学基金 (81260192)。 |
摘要
目的：探究血清胆红素水平与大动脉炎(takayasu arteritis，TA)之间的相关性。方法：共纳入110例TA患者(TA组)，193例健康受试者(对照组)。并对活动性TA患者进行泼尼松治疗。结果：与健康对照组比较，TA组血清胆红素显著下降(0.6±0.32 mg/dL vs 0.7±0.21 mg/dL，P=0.02)，差异有统计学意义；活动性TA患者血清胆红素水平低于非活动性TA患者(0.5±0.22 mg/dL vs 0.8±0.31 mg/dL， P<0.001)，差异有统计学意义；多元回归分析发现血清胆红素水平与红细胞沉降率具有负相关性(β=−0.171，P<0.001)，差异有统计学意义；活动性TA患者使用泼尼松治疗后，血清胆红素水平较治疗前显著升高(0.5±0.21 mg/dL vs 0.7±0.14 mg/dL，P=0.002)，差异有统计学意义。结论：TA患者血清胆红素下降，且胆红素水平变化受到泼尼松治疗的影响，TA患者血清胆红素水平与红细胞沉降率负相关。
关键词：
血清胆红素；大动脉炎；相关性
Relationship between serum bilirubin levels and patients with takayasu arteritis
CorrespondingAuthor: LEI Yuhua Email: huayulei_0319@126.com
DOI: 10.3978/j.issn.2095-6959.2019.04.019
Foundation: This work was supported by National Natural Science Foundation of China (81260192).
Abstract
Objective: To investigate the relationship between serum bilirubin and takayasu arteritis (TA). Methods: Our study involved 110 consecutive TA patients and 193 healthy controls. Patients with active-phase disease were followed and received prednisone therapy. Results: Lower concentrations of serum bilirubin were detected in TA patients compared with healthy subjects (0.6±0.32 mg/dL vs 0.7±0.21 mg/dL, P=0.02). Serum bilirubin concentrations in active TA patients were lower than those in inactive patients (0.5±0.22 mg/dL vs 0.8± 0.31 mg/dL, P<0.001). Serum bilirubin was negatively correlated with erythrocyte sedimentation rate (β=−0.171, P<0.001) in multiple linear regression analysis. Serum bilirubin levels were found to be significantly increased after prednisone treatment (0.5±0.21 mg/dL vs 0.7±0.14 mg/dL, P=0.002). Conclusion: Lower serum bilirubin levels are associated with TA, and serum bilirubin may be influenced by prednisone therapy in active TA patients. Serum bilirubin levels in TA patients correlate negatively with erythrocyte sedimentation rate.
Keywords：
serum bilirubin; takayasu arteritis; relationship