P-gp与pCEA，CD10在肝细胞癌毛细胆管中表达的比较及其在肝细胞癌诊断中的价值
| 作者: |
1孙薇,
2赵有财,
2田智丹,
2杨小兵,
2王劲松,
2王晓蕾,
2吕倩,
2黄文斌
1 江苏卫生健康职业学院病理学教研室，南京 210029 2 南京医科大学附属南京医院/南京市第一医院病理科，南京 210006 |
| 通讯: |
赵有财
Email: 893110640@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.007 |
| 基金: | 南京市医学科技发展项目 (YKK18098)。 |
摘要
目的：比较P-糖蛋白(P-glycoprotein，P-gp) 与pCEA，CD10在肝细胞癌( hepatocel lular carcinoma，HCC)毛细胆管中的表达，探讨P-gp在HCC诊断中的价值。方法：应用免疫组织化学EnVision法对36例不同分化程度的HCC组织进行P-gp，pCEA，CD10标记，观察它们在毛细胆管中表达的情况。结果：P-gp，pCEA和CD10在HCC毛细胆管着色的阳性率分别为80.6%(29/36)， 75%(27/36)和55.6%(20/36)；3个标志物中P-gp的表达较弥漫；P-gp，pCEA和CD10阳性率随着HCC分化程度的降低而降低。结论：P-gp在HCC毛细胆管中表达的阳性率与pCEA相似，两者均高于CD10，P-gp可作为HCC的辅助诊断标志物。
关键词：
肝细胞癌；毛细胆管；P-糖蛋白；pCEA；CD10
Comparison of the expression of P-gp, pCEA and CD10 in the bile canaliculi of hepatocellular carcinoma
CorrespondingAuthor: ZHAO Youcai Email: 893110640@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.04.007
Foundation: This work was supported by Nanjing Medical Science and Technology Development Foundation, China (YKK18098).
Abstract
Objective: To compare the expression of P-gp, pCEA and CD10 in the bile canaliculi of hepatocellular carcinoma (HCC), and to explore the value of P-gp in the diagnosis of HCC. Methods: Immunohistochemical study (EnVision method) was used to detect the expression of P-gp, pCEA and CD10 in 36 cases of HCCs with different degrees of differentiation, and the expression of them in the bile canaliculi were observed. Results: The positive rate of P-gp, pCEA and CD10 in HCC (canalicular staining pattern) were 80.6% (29/36), 75% (27/36) and 55.6% (20/36), respectively. The expression of P-gp is the most extensive in the 3 markers. It’s positive rate decreased from well to poorly differentiated HCCs. Conclusion: P-gp could be a valuable marker in the assistant diagnosis of HCC. The positive rate of P-gp in the bile canaliculi of HCC was similar to that of pCEA, both were higher than that of CD10.
Keywords：
hepatocellular carcinoma; bile canaliculi; P-glycoprotein; pCEA; CD10