8 例肠黏膜相关淋巴组织淋巴瘤的临床病理特征
| 作者: |
1兰智华,
1赵强,
1贺荣芳,
1马昕,
1张小丽
1 南华大学附属第一医院病理科，湖南 衡阳 421001 |
| 通讯: |
赵强
Email: 276020102@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.03.038 |
| 基金: | 湖南省卫生与计划生育委员会科研计划课题项目 (B20180052)。 |
摘要
回顾性分析7例经手术切除标本及1例肠镜活检标本，进行常规切片、免疫组织化学染色，结合临床病理特征进行总结并复习文献。8例肠黏膜相关淋巴组织淋巴瘤病例，男6例，女2例，年龄平均61岁，5例临床诊断为肠癌，2例为间质瘤，1例为胰腺癌。镜下可见嗜黏膜现象，中等大小的淋巴样细胞在固有层弥漫浸润。免疫组织化学示CD79α及CD20强阳性，cyclinD1阴性。肠黏膜相关淋巴瘤是少见的肠道疾病，病理诊断时应鉴别其他小B细胞淋巴瘤及软组织或神经系统圆形细胞恶性肿瘤。同时需要谨慎观察是否向大B细胞淋巴瘤转化。
关键词：
肠黏膜相关淋巴组织淋巴瘤；临床病理特征；CD79α；CD20
Clinicopathological features of eight cases of intestinal mucosa-associated lymphoid tissue lymphoma
CorrespondingAuthor: ZHAO Qiang Email: 276020102@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.03.038
Foundation: This work was supported by Hunan Research Projects of Health and Family Planning, China (B20180052).
Abstract
The specimens from seven surgical excisions and a biopsy sample were retrospectively analyzed, including hematoxylin-eosin (HE) staining, immunohistochemical staining methods, and their clinicopathological features were summarized and the literatures were reviewed. The patients included six males and two females, and the average age was 61 years old. Among them, five cases were clinically diagnosed as intestinal carcinoma, two cases as mesenchymoma, and the other one as pancreatic carcinoma. Epitheliotropic intermediated sized lymphoma cells grow in infiltration pattern in lamina propria could be observed in histology. The CD79α and CD20 were positively expressed in these tumor cells with immunohistochemical staining. However, the cyclinD1 expressed negatively. Intestinal mucosa-associated lymphoid tissue lymphoma is a rare type intestinal disease. Differential diagnosis includes other small B cell lymphomas and round cell tumors of soft tissue or nervous system. Meanwhile, whether intermediated tumor cells transform to Large B cells should be observed carefully in pathological diagnosis.
Keywords：
intestinal mucosa-associated lymphoid tissue lymphoma; clinicopathological feature; CD79α; CD20