慢性炎症与胰岛素抵抗机制关系的研究进展
| 作者: |
1魏伊秋,
1李满,
1余佳
1 武汉大学人民医院肝胆外科，武汉 430060 |
| 通讯: |
余佳
Email: hbpennhmp116@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.03.030 |
| 基金: | 中国留学基金委员会 [ 留金发 (2017)3059 号 ]；武汉市医学中青年骨干人才项目 [(2016)59]。 |
摘要
胰岛素抵抗(insulin resistance，IR)的发生是一个慢性炎症过程，IR的机制与炎症密切相关。炎症因子能参与胰岛素信号通路干扰其信号转导，也可与氧化应激(oxidative stress，OS)过程相互作用加重IR，且炎症是连接肥胖与IR的桥梁，脂肪组织产生的炎症因子和脂肪细胞因子可通过调节炎症反应影响胰岛素作用过程，一些研究也表明抗炎治疗能改善IR。阐明慢性炎症与IR机制关系，有助于对研究IR及与其密切相关的2型糖尿病、代谢综合征等开拓新思路，为新药研发提供更多理论和实践依据。
关键词：
胰岛素抵抗；慢性炎症；2型糖尿病
Research progress in the relationship between chronic inflammation and insulin resistance
CorrespondingAuthor: YU Jia Email: hbpennhmp116@163.com
DOI: 10.3978/j.issn.2095-6959.2019.03.030
Foundation: This work was supported by the China Scholarship Council [CSC (2017) No. 3059] and Wuhan Young and Middle-aged Medical Backbone Talent Training Project [(2016)59], China .
Abstract
Insulin resistance (IR) is a chronic inflammatory process, and the mechanism of IR is closely related to inflammation. Inflammatory factors can participate in the insulin signaling pathway to interfere with its signal transduction, and can also interact with the oxidative stress process to aggravate IR. Inflammation is also a bridge that connecting obesity and IR. Adipose tissue inflammatory cytokines and adipocytokines may affect the process of insulin action by regulating the inflammatory response, and some studies have shown that anti-inflammatory treatment can improve IR. Elucidating the relationship between chronic inflammation and the mechanism of IR is help to develop new ideas for studying IR and its closely related diseases like type 2 diabetes and metabolic syndrome, and provide more theoretical and practical basis for new drug research and development.
Keywords：
insulin resistance; chronic inflammation; type 2 diabetes mellitus