2 型糖尿病患者胱抑素 C、血尿酸与颈动脉内膜中层厚度的关系
| 作者: |
1司玮,
1马维青,
1吕芳,
1王国娟,
1胡国平,
1张强,
1刘皆,
1孙春萍,
1张伟
1 合肥市第一人民医院内分泌科，合肥 230061 |
| 通讯: |
马维青
Email: maweiqingzr@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.03.017 |
| 基金: | 合肥市第五周期重点培育专科建设项目 (2016256)。 |
摘要
目的：探讨2型糖尿病(t y pe 2 diabetes mel litus，T2DM)患者胱抑素C(c ystatin C，CysC)、血尿酸(serum uric acid，SUA)与颈动脉内膜中层厚度(carotid intima-media thickness，CIMT)的关系。方法：选取2017年12月至2018年9月于合肥市第一人民医院内分泌科住院的71例T2DM患者为研究对象，根据CIMT值将其分为A组(CIMT正常组：CIMT<1.0 mm；35例)与B组(CIMT增厚组：CIMT≥1.0 mm；36例)，比较两组患者临床资料及CysC，SUA等生化指标水平，分析其对CIMT的影响。结果：B组年龄、病程、收缩压、空腹血糖、糖化血红蛋白、CysC、SUA均高于A组，差异有统计学意义(P<0.05)。T2DM患者的CIMT与CysC，SUA呈正相关(P<0.05)，CysC，SUA是影响CIMT的危险因素(P<0.05)。结论：T2DM患者的CysC，SUA水平与CIMT密切相关。
关键词：
2型糖尿病；胱抑素C；血尿酸；颈动脉内膜中层厚度
Association of cystatin C and serum uric acid with carotid intima-media thickness in type 2 diabetes mellitus
CorrespondingAuthor: MA Weiqing Email: maweiqingzr@126.com
DOI: 10.3978/j.issn.2095-6959.2019.03.017
Foundation: This work was supported by the Hefei Fifth Cycle Focus on Training Specialist Projects, China (2016256).
Abstract
Objective: To explore the relationship between cystatin C (CysC) and serum uric acid (SUA) with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) patients. Methods: Seventy-one patients with T2DM hospitalized in the Department of Endocrinology from December 2017 to September 2018 were selected as subjects. According to the CIMT value, they were divided into group A (normal CIMT group: CIMT <1.0 mm; n=35) and group B (CIMT thickening group: CIMT ≥1.0 mm; n=36). The clinical data, CysC, SUA and other biochemical indexes of the two groups were compared, and the effects on CIMT were analyzed. Results: The age, course of disease, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, CysC, SUA in group B were higher than those in group A, and the difference was statistically significant (P<0.05). CIMT was correlated with CysC and SUA in patients with T2DM (P<0.05). CysC and SUA were risk factors for CIMT (P<0.05). Conclusion: The levels of CysC and SUA in T2DM patients are closely related to CIMT.
Keywords：
type 2 diabetes mellitus; cystatin C; serum uric acid; carotid intima-media thickness