Objective: To investigate the prognostic role of left atrial minimal volume (LAV_min) in patients with non-obstructive hypertrophic cardiomyopathy (HCM) and to test if LAV_min is better than left atrial maximum volume (LAV_max) in predicting clinical outcome. Methods: A total of 167 consecutive patients with non-obstructive HCM were enrolled [age (64.6±13.4) years, male:female = 120:47]. Patients had cardiovascular events (heart failure hospitalization, stroke, death) were also investigated. Clinical parameters and conventional echocardiographic measurement were measured. The relationship between LAV_min and the clinical outcome was evaluated. Results: During a median follow-up of (25.0±17.7) months, the cardiovascular events occurred in 35 patients (21%). And the 35 patients were placed in the observation group. LAV_max and LAV_min were higher in the observation group than the control group (all P<0.001). By means of multi-variable analysis, we found that LAV_min and LAV_max were predictive of cardiovascular events after adjustment for age, diabetes, hypertension, atrial fibrillation, LV ejection fraction, and E/e’ (P=0.001). By ROC analysis, we found that the model including indexed LAV_min was superior to the model including indexed LAV_max in predicting a worse outcome in patients with HCM (0.85 vs 0.82, P=0.02). Conclusion: LAV_min is independently associated with increased risk of HF, stroke, or mortality in patients with HCM and is superior to LAV_max in predicting clinical outcome in this population.