线粒体动力学与心血管疾病的相关性
| 作者: |
1努尔巴哈尔·热木图拉,
1彭辉
1 新疆维吾尔自治区人民医院心内科，乌鲁木齐 830001 |
| 通讯: |
彭辉
Email: lucy-ph@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.02.028 |
| 基金: | 新疆维吾尔自治区自然科学基金 (2017D01C131)。 |
摘要
线粒体通过不断地融合与分裂来保持线粒体稳态，即线粒体动力学，由线粒体分裂和融合蛋白精确调控完成的，包括动力相关蛋白1(dynamin-related protein 1，DRP1)、线粒体融合蛋白1/2((mitofusin-1/2，MFN1/2)及视神经萎缩蛋白-1(optic atrophy 1，OPA1)等。当心肌细胞线粒体融合与分裂过程失衡时则会引起自身形态和功能紊乱，进而损害心脏结构和功能，参与缺血-再灌注损伤(ischemia-reperfusion injury，IRI)，心力衰竭(heart failure，HF)及糖尿病性心肌病等疾病的发生与进展。
关键词：
线粒体动力学；缺血-再灌注；心力衰竭；糖尿病心肌病
Correlation between mitochondrial dynamics and cardiovascular diseases
CorrespondingAuthor: PENG Hui Email: lucy-ph@163.com
DOI: 10.3978/j.issn.2095-6959.2019.02.028
Foundation: This work was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region, China (2017D01C131).
Abstract
Mitochondria maintains mitochondrial homeostasis through continuous division and fusion, that is, mitochondrial dynamics, changes in mitochondrial dynamics are related to the pathogenesis of diseases such as ischemia-reperfusion injury (IRI), heart failure, and diabetic cardiomyopathy. Mitochondrial dynamics is accurately regulated by mitochondrial division and fusion proteins, including dynamin-related protein 1 (DRP1), mitochondrial fusion protein 1/2 (mitofusin-1/2, mfn1/2) and optic atrophy 1 (OPA1). These proteins are closely regulated by a number of signaling pathways, including transcription, post-translational modification (PTMs), and protein-dependent degradation.
Keywords：
mitochondrial dynamics; ischemia-reperfusion; heart failure; diabetic cardiomyopathy