Objective: To explore the effects of acupuncture combined with sensory integration training and exercise intervention on autistic children. Methods: Sixty autistic children in the hospital were divided into an observation group and a control group by the random number table method, with 30 children in each group. The control group was given sensory integration training and exercise intervention, while the observation group was treated with scalp acupuncture on the basis of the control group. All children were treated for 6 months. The Child Autism Rating Scale (CARS) and the Autism Behavior Checklist (ABC) were used to evaluate the core symptoms of autism. The Sensory Integration Development Assessment Scale was used to evaluate the recovery of sensory integration ability and the balance ability was observed. Results: After the treatment, CARS scores and scores of sense, communication, physical exercise and language and the total score of ABC in the observation group were lower than those in the control group (P<0.05). After the treatment, scores of vestibular dysfunction, excessive tactile defense, proprioceptive disturbance, lack of learning ability and sensory integration dysfunction in the observation group were significantly higher than those in the control group (P<0.05). The time of eye opening and eye closure of the observation group was longer than that of the control group, while the walking time on balance beam was shorter than that of the control group (P<0.05). Conclusion: Acupuncture combined with sensory integration training and exercise intervention can decrease core symptoms and further relieve sensory integration disorders in autistic children.