Objective: To observe the effects of epidural analgesia and intravenous analgesia on stress, T-lymphocyte subsets, tumor factors and survival of ovarian tumor patients undergoing ovarian tumor reduction. Methods: From January 2013 to January 2015, 84 patients with ovarian cancer were selected as the research objects, all patients were performed tumor cells to destroy the loss, in accordance with the laws of random numbers, they were divided into two groups, each group of 42 cases. Epidural analgesia was used in epidural analgesia group. Intravenous analgesia was used in the intravenous analgesia group. Two groups of patients with operation time, blood loss and length of hospital stay were recorded. Two groups of patients before surgery 30 min, 24 h, 48 h and 72 h after surgery stress index cortisol (CRH), growth hormone (GH) and prostaglandin E2 (PGE2), T lymphocyte subsets CD3⁺, CD4⁺ and CD8⁺ and CD4⁺/CD8⁺ ratios, tumor necrosis factor-α (TNF-α), and 3-year survival rate differences were compared. Results: The operative time, intraoperative blood loss and hospitalization time of the two groups were not statistically significant (P>0.05). CRH, GH, PGE2 and TNF-α were not statistically significant in the two groups 30min before surgery (P>0.05). CRH, GH, PGE2 and TNF-α decreased at 24, 48 and 72 h after the surgery (F_time=42.471, 14.162, 78.918, 10.354; P<0.05), and the change range of epidural analgesia was significantly higher than that of intravenous analgesia (F_group*time=39.415, 13.997, 70.244, 9.168; P<0.05). T lymphocyte changes in the two groups were not statistically significant 30 min before the surgery (P>0.05). CD3⁺, CD4⁺ and CD4⁺/CD8⁺ decreased first and then increased, while CD8⁺ decreased first and then decreased (F_time=12.581, 17.162, 18.872, 14.946, P<0.05). CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were significantly higher in the epidural analgesia group than in the intravenous analgesia group, while CD8⁺ was significantly lower than in the intravenous analgesia group (F_group=11.037, 14.536, 15.718, 10.718; P<0.05). The change range of the epidural analgesia group was significantly higher than that of the intravenous analgesia group (F_group*_time=9.425, 15.815, 16.714, 12.019; P<0.05). All patients were followed up, and the three-year survival rate was 35.70% (15/42) in the epidural analgesia group and 33.30% (14/42) in the intravenous analgesia group, with no statistical significance (P=0.680). Conclusion: Epidural analgesia can reduce the stress response of patients and protect the body’s immune function, but the effect on the survival rate of patients is not obvious.