鼻咽睾丸核蛋白癌1例并文献回顾
| 作者: |
1康婷芳,
1赵京,
1叶小卫
1 广州中医药大学第一附属医院肿瘤中心，广州 510400 |
| 通讯: |
叶小卫
Email: billye983@aliyun.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.01.038 |
| 基金: | 广东省中医药局科研项目(20164011)。 |
摘要
对1例鼻咽睾丸核蛋白(nuclear protein of the testis，NUT)癌的临床及病理特征进行回顾性分析，并结合文献复习。NUT癌镜下见条索状或巢片状生长的肿瘤细胞，其间见纤维黏液样间质，肿瘤细胞质呈淡嗜伊红色，细胞核增大，核形不规则，核染色质粗，部分细胞可见核仁，偶见核分裂象。免疫组织化学：NUT阳性，AE1/AE3，Syn，CgA，CD56有不同程度的表达，S-100，P63，前列腺特异抗原(prostate-specific antigen，PSA)，前列腺特异抗原密度(prostate-specific antigen density，PSAD)均阴性。NUT癌是高度侵袭性肿瘤，病理学特征、免疫组织化学检查结果、NUT抗体是其重要的诊断依据。
关键词：
睾丸核蛋白；癌；鼻腔；免疫组织化学
Nuclear protein of the testis carcinoma of the nasal cavity: A case report and review of literature
CorrespondingAuthor: YE Xiaowei Email: billye983@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2019.01.038
Foundation: This work was supported by the Guangdong Traditional Chinese Medicine Bureau Research Project, China (20164011).
Abstract
The clinical and pathological features of a case of nuclear protein of the testis (NUT) were analyzed and discussed in the literature. NUT carcinoma showed chord-like or nest-like tumor cells with fibromyxoid stroma between them. The cytoplasm of tumor cells was light eosinophilic, with enlarged nuclei, irregular nuclear shape, rough nuclear chromatin and some cells with nucleoli and occasional mitotic figures. Immunohistochemistry showed that NUT positive, AE1/AE3, SYN, CgA, CD56 had different degrees of expression, and S-100, P63, prostatespecific antigen (PSA), prostate specific antigen density (PSAD) were negative. NUT is a highly invasive tumor. Pathological features, immunohistochemistry and NUT antibodies are important diagnostic criteria.
Keywords：
nuclear protein of the testis; carcinoma; nasal cavity; immunohistochemistry