肿瘤相关血小板RNA 用于恶性肿瘤液体活检的研究进展
| 作者: |
1范怡畅,
1俞静
1 首都医科大学附属北京友谊医院肿瘤中心，北京 100050 |
| 通讯: |
俞静
Email: yujing026@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.01.031 |
| 基金: | 国家自然科学基金(81774221)；首都卫生发展科研专项项目(2018-2-1113)；首都医科大学基础- 临床科研合作基金(17JL14)；首都医科大学附属北京友谊医院科研启动基金(yyqdkt2016-4)。 |
摘要
随着精准医疗概念的提出，恶性肿瘤的早期筛检及基于肿瘤基因检测的靶向治疗成为一个重要的研究方向。对肿瘤组织进行病理诊断并进行相关基因检测是目前进行肿瘤诊断和制定治疗策略的重要基石。组织活检因其有创性、高风险性、难以重复性及异质性，在临床应用中受到一定的限制。而液体活检则是组织活检有效的补充，它是一种新型的微创检测方法，可通过分析个体化的基因表达谱，提高检测的准确性，降低检测成本。目前液体活检方法如循环肿瘤DNA(circulating tumor DNA，ctDNA)、循环肿瘤细胞(circulating tumor cell，CTC)、血小板RNA等用于肿瘤检测的研究已取得一定的进展。
关键词：
肿瘤相关血小板RNA；非小细胞肺癌；液体活检
Research progress of tumor-educated platelets RNA in liquid biopsy of non-small cell lung cancer
CorrespondingAuthor: YU Jing Email: yujing026@163.com
DOI: 10.3978/j.issn.2095-6959.2019.01.031
Foundation: This work was supported by the National Natural Science Foundation (81774221), Capital Health Research and Development of Special Project (2018-2-1113)
Abstract
With proposing the concept of precision medicine, early diagnosis of malignant tumor and targeted therapy based on tumor gene detection have become an important development trend. Pathological analysis and related genetic analysis of the tumor tissue are important criteria for tumor diagnosis and treatment. Tissue biopsy is restricted in clinical application because of invasive, high risk, difficult repeat-ability and heterogeneity. And liquid biopsy is a kind of new minimally invasive detect method to analyze individualized gene expression profiles, supplying for tissue biopsy. Moreover, it could improve the accuracy of detection and reduce the testing cost. Currently, circulating tumor DNA (ctDNA), circulating tumor cells (CTC), platelet RNA has been used for liquid biopsy and made some progress.
Keywords：
tumor-educated platelets RNA; non-small cell lung cancer; liquid biopsy