Objective: To discuss Mammotome minimally invasive surgery for breast neoplasms value and applicability. Methods: A retrospective analysis was made of 44 patients with malignant lesions of the breast from September 2007 to December 2017 of Foshan Maternal and Child Health Care Hospital affiliated to Southern Medical University. Compared and analyzed the clinical data, clinical features and postoperative pathological results. Results: A total of 44 cases surgery by postoperative pathology confirmed breast cancer. The diameter of the tumor ranged from 0.5 to 3.0 cm. The pathological types included 16 cases ductal carcinoma in situ, 10 non-special invasive carcinoma, 7 cases non-special invasive carcinoma and ductal carcinoma in situ, 2 cases non-special invasive carcinoma and mucinous carcinoma, 4 cases invasive lobular carcinoma, 2 cases mucinous carcinoma, 1 cases infiltrative perspiration adenocarcinoma, 1 case of secretory carcinoma and 1 cases tubule carcinoma. After pathological diagnosis of malignancy, all patients underwent extended resection or simple mastectomy plus axillary sentinel lymph node biopsy or modified radical mastectomy within 1 to 10 d. Conclusion: Mammotome surgery can partly cut the complete resection of breast cancer, but there are some residual lesions, if suspicious as malignancy as far as possible to avoid Mammotome surgery.