Objective: To further understand granular cell tumor (GCT) and to improve diagnostic accuracy through analyzing the clinicopathological features, the immune phenotype, diagnosis, differential diagnosis and prognosis of GCT. Methods: The clinical features, morphologic changes and immune phenotypes of 10 cases of GCT were retrospectively analyzed and relevant literatures were reviewed. Results: Ten GCT cases had similar histologic morphology. The tumor cells were large, polygonal, round or oval, with small nuclei and abundant cytoplasm that was rich in eosinophilic particles. The tumor cells invaded the surrounding tissues, and some of them grew peripherally around the small nerve bundle. The immunohistochemical analysis showed that the tumor cells expressed S-100 protein and neuron-specific enolase (NSE), most of which expressed CD68, but did not express cytokeratin (AE1/AE3), Desmin, smooth muscle actin (SMA), muscle specific actin (MSA), Melan-A or HMB45. The Ki-67 proliferation index was low, usually below 3%. Conclusion: GCT is a rare soft tissue tumor, whose preoperative diagnose is difficult. Surgery is the main treatment. Benign cases show good prognosis. Very few cases are malignant with poor prognosis.