甲状旁腺激素相关蛋白对骨关节炎软骨细胞修复的作用机制及应用进展
| 作者: |
1李啸宇,
2黎润光
1 南方医科大学第一临床医学院，广州 510515 2 南方医科大学南方医院创伤骨科，广州 510515 |
| 通讯: |
黎润光
Email: lirunguang79@163.com |
| DOI: | 10.3978/j.issn.2095-6959. 2018.12.033 |
| 基金: | 广东省自然科学基金(2018A03031364)；南方医科大学省级大学生创新训练计划项目(201712121134)。 |
摘要
甲状旁腺激素相关蛋白(parathyroid hormone-related peptide，PTHrP)与关节软骨细胞有关的作用机制，包括在生长发育过程中与调节软骨内成骨过程相关的作用机制，在生理状态下与维持关节软骨正常形态相关的作用机制，及其与骨关节炎(osteoarthritis，OA)关节软骨发病过程中的相关的作用机制。探究PTHrP在OA治疗中的应用，包括其中央区及C端肽段的独特作用及影响其效果的不同因素，如施加时间的间隔、每次施加的时间长度及施加的时间点。
关键词：
甲状旁腺激素相关蛋白；骨关节炎；软骨内成骨；关节软骨；治疗
Mechanism and application of parathyroid hormone-related proteins on the repair of osteoarthritis cartilage cells
CorrespondingAuthor: LI Runguang Email: lirunguang79@163.com
DOI: 10.3978/j.issn.2095-6959. 2018.12.033
Foundation: This work was supported by the Natural Science Foundation of Guangdong Province (2018A03031364) and Provincial Student’s Platform for Innovation and Entrepreneurship Training Program of Southern Medical University (201712121134), China.
Abstract
The mechanisms of parathyroid hormone-related protein (PTHrP) concerning about articular cartilage cells included regulating endochondral ossification during the process of growth and development, keeping the normal articular cartilage form in a physiological manner, and preventing osteoarthritis (OA). Then we introduced the application of PTHrP in treatment of OA, including the unique functions of the central region and the C-terminal peptides of PTHrP and the factors influencing its effects, such as the interval of time, length of time and the time point of applying.
Keywords：
parathyroid hormone-related protein; osteoarthritis; endochondral ossification; articular cartilage; treatment