Objective: To observe the clinical efficacy and safety of electroacupuncture combined with wumu pill in the treatment of Sjogren’s syndrome. Methods: Seventy-six cases of Sjogren’s syndrome were randomly divided into 2 groups, and 36 cases in the control group were treated with hydroxychloroquine sulfate; 40 cases in the treatment group were treated with electroacupuncture combined with wumei pill based on the control group. A course of 12 weeks. Changes in clinical TCM syndromes, Shirmer test, saliva flow rate, CRP, IgG and ESR were observed before and after treatment in the two groups. Results: After the treatment, the curative effect of TCM syndrome was compared, and the treatment group was significantly better than that of the control group, with statistically significant differences (P<0.05). Shirmer test, saliva flow rate, CRP, IgG and ESR were significantly improved in the treatment group compared with those before treatment (P<0.05). The Schimer test, saliva flow rate, and CRP of the control group were improved compared with those before treatment (P<0.05). All the observation indexes were compared, and the treatment group was superior to the control group (P<0.05). In terms of safety, adverse reactions were less in both groups, and symptomatic treatment was relieved. Conclusion: The combined treatment of Sjogren’s syndrome with electroacupuncture and umei pill plus or minus hydroxychloroquine sulfate has synergistic effect, positive effect, high safety and less adverse reactions.