III型前列腺炎患者前列腺按摩液中NE，pH，IL-1β，TNF-α及PGE2的变化及其意义
| 作者: |
1杨杰
1 安阳市第三人民医院泌尿外科，河南 安阳 455000 |
| 通讯: |
杨杰
Email: gyslxs@126.com |
| DOI: | 10.3978/j.issn.2095-6959. 2018.12.009 |
摘要
目的：探讨III型前列腺炎患者前列腺按摩液(expressed prostatic secretion，EPS)中中性粒细胞弹性蛋白酶(neutrophil elastase，NE)，pH值，IL -1β，TNF-α、前列腺素E2(prostaglandin E2，PGE2)水平的变化及其意义。方法：选取2016年4月至2017年5月安阳市第三人民医院收集的60例IIIA型前列腺炎患者(A组)、60例IIIB型前列腺炎患者(B组)、健康男性60例(C组)，检测三组EPS中NE，pH值， IL-1β，TNF-α，PGE2水平，并分析其与慢性前列腺炎症状评分(chronic prostatitis symptoms score， NIH-CPSI)、白细胞(white blood cell，WBC)计数的关系。结果：A组EPS中NE，pH，IL-1β，TNF-α及PGE2水平均显著高于B组和C组，差异具有统计学意义(P<0.05)；B组和C组EPS中NE，pH，IL -1β，TNF-α及PGE2水平差异均无统计学意义(P>0.05)；A组EPS中白细胞计数均显著高于B组和C组，差异具有统计学意义(P<0.05)，A组和B组的NIH-CPSI评分差异无统计学意义(P>0.05)；B组和C组的白细胞计数差异均无统计学意义(P>0.05)；IIIA型前列腺炎患者EPS中NE，pH，IL -1β， TNF-α及PGE2水平与白细胞计数均呈正相关(P<0.05)，与NIH-CPSI评分无相关性(P>0.05)；IIIB型前列腺炎患者EPS中NE，pH，IL-1β，TNF-α及PGE2水平与白细胞计数、NIH-CPSI评分均无相关性(P>0.05)。结论：IIIA型前列腺炎患者EPS中NE，pH，IL -1β，TNF-α及PGE2水平与IIIB型患者存在差异，并且在一定程度上可以反映IIIA型患者的病情严重程度。
关键词：
前列腺炎；前列腺按摩液；中性粒细胞弹性蛋白酶；pH值；白细胞介素-1β；肿瘤坏死因子-α；前列腺素E2
Changes and significance of NE, pH, IL-1β, TNF-α and PGE2 in EPS patients with type III prostatitis
CorrespondingAuthor: YANG Jie Email: gyslxs@126.com
DOI: 10.3978/j.issn.2095-6959. 2018.12.009
Abstract
Objective: To investigate the changes and significance of neutrophil elastase (NE), pH, IL-1β, TNF-α and prostaglandin E2 (PGE2) in expressed prostatic secretion (EPS) of patients with type III prostatitis. Methods: A total of 60 patients with type IIIA prostatitis (group A), 60 patients with type IIIB prostatitis (group B) and 60 healthy men (group C) were enrolled in our hospital from April 2016 to May 2017, The levels of NE, pH, IL-1β, TNF-α and PGE2 in the EPS of the three groups were detected and their relationship with NIH-CPSI and white blood cell count were analyzed. Results: The levels of NE, pH, IL-1β, TNF-α and PGE2 in EPS in group A were significantly higher than those in groups B and C (P<0.05); in EPS in groups B and C The levels of NE, PH, IL-1β, TNF-α and PGE2 were not statistically different (P>0.05). The leukocyte counts of EPS in group A were significantly higher than those in group B and C (P<0.05). There was no significant difference in NIH-CPSI score between group A and group B (P>0.05). There was no significant difference in white blood cell count between groups B and C (P>0.05). The levels of NE, pH, IL-1β, TNF-α and PGE2 in EPS of type IIIA prostatitis were positively correlated with leukocyte count (P<0.05), but not with the NIH-CPSI score (P>0.05). The levels of NE, pH, IL-1β, TNF-α and PGE2 in EPS of type IIIB prostatitis had no significant correlation with leukocyte count and NIH-CPSI score (P>0.05). Conclusion: The levels of NE, pH, IL-1β, TNF-α and PGE2 in EPS of patients with type IIIA prostatitis are different from those of type IIIB, and to a certain extent, the severity of patients with type IIIA can be reflected.
Keywords：
prostatitis; prostate massage fluid; Neutrophil elastase; pH value; interleukin-1β; tumor necrosis factor-α; prostaglandin E2