血清胸苷激酶1在肝门胆管癌中的临床价值
| 作者: |
1李华,
1贺文财,
1汪学昌,
2田伟峰
1 青海省第五人民医院放疗一科，青海 西宁 810007 2 青海省第五人民医院中西结合科，青海 西宁 810007 |
| 通讯: |
李华
Email: 303590477@qq.com |
| DOI: | 10.3978/j.issn.2095-6959. 2018.12.007 |
摘要
目的：探究胸苷激酶1(thymidine kinase 1，TK1)在肝门胆管癌中的临床价值。方法：纳入2005年9月至2011年6月青海省第五人民医院的72例肝门胆管癌患者，采用化学发光斑点杂交法检测血清TK1水平，并分析肝门胆管癌患者血清TK1水平与临床病理特征及预后的关系。结果：肝门胆管癌患者血清TK1水平明显高于健康人者血清TK1水平。血清TK1表达水平与肿瘤最大径(P=0.002)， Bi smuth-Corlette分期(P<0.001)和淋巴结转移(P<0.001)表达密切相关。生存分析发现分化程度(HR=2.089，P=0.024)和血清TK1水平(HR=2.519，P=0.018)为肝门胆管癌患者总生存期(overall sur vival，OS)独立预后因素，而血清TK1水平(HR=3.694，P=0.003)为本组肝门胆管癌患者无进展生存期(progression-free sur vival，PFS)独立预后因素。血清TK1水平较高的肝门胆管癌患者OS和PFS较短。结论：TK1可能与肝门胆管癌的发生发展密切相关，血清TK1水平能预测肝门胆管癌患者预后。
关键词：
肝门胆管癌；胸苷激酶1；预后
Clinical value of serum thymidine kinase 1 in hilar cholangiocarcinoma
CorrespondingAuthor: LI Hua Email: 303590477@qq.com
DOI: 10.3978/j.issn.2095-6959. 2018.12.007
Abstract
Objective: To study the clinical application value of thymidine kinase 1 (TK1) in hilar cholangiocarcinoma (HC). Methods: We collected 72 patients with hilar cholangiocarcinoma from September 2005 to June 2011 in Fifth People’s Hospital of Qinghai Province. Serum TK1 was detected by chemiluminescence dot blot assay, the potential relevance to clinicopathological characteristics and prognostic significance of serum TK1 in HC patients were also investigated. Results: The serum TK1 level in HC patients was significantly higher than those in healthy people. The expression of serum TK1 was closely related to tumor size (P=0.002), Bismuth-Corlette stage (P<0.001) and lymph node metastasis (P<0.001). Survival analysis revealed that differentiation (HR=2.089, P=0.024) and serum TK1 (HR=2.519, P=0.018) were independent prognostic factors for overall survival (OS) in patients with hilar cholangiocarcinoma. And serum TK1 (HR =3.694, P=0.003) was an independent prognostic factor for progression-free survival (PFS) in patients with hilar cholangiocarcinoma. Patients with higher serum TK1 level presented shorter OS and PFS than those with normal serum TK1 level. Conclusion: TK1 plays an important role in the aggressiveness of HC and higher serum TK1 level indicates the poor prognosis for HC patients.
Keywords：
hilar cholangiocarcinoma; thymidine kinase 1; prognosis