Objective: To investigate the clinicopathological features, immunophenotype and biological behavior of solitary fibrous tumor (SFT). Methods: We enrolled 11 cases of SFT and reviewed medical records. Histopathological and Immunohistochemical analysis was performed on them. Clinical follow-up was performed on all cases (1–48 months). Results: Among the 11 cases of SFT, including 8 males and 3 females, aged 40 to 76 years, 2 cases were malignant, 1 case recurred and 2 cases died from disease. Histologically, SFT are characterized by alternating hypercellular and hypocellular areas. Tumor cells arrange in a discernible architecture with ropy collagen fibers. Hemangiopericytoma (HPC)-like architecture is common. However, the malignant counterparts have distinct morphology and high proliferation index. Immunostaining for STAT6 and CD34 are consistently positive, while bcl-2 and CD99 staining are less sensitive. Notably, the expression of CD34 can be lost in malignant SFT. Conclusion: SFT is a relatively rare mesenchymal tumor with specific morphology, which shows intermediate to malignant behavior. Appropriate immunohistochemical analysis can help pathologists avoid misdiagnosis and differentiate from other spindle cell tumors.