Objective: To investigate the clinical efficacy of Erhuang Capsule benefit for Kidney combined with conventional therapy in the treatment of stage IV diabetic kidney disease (DKD) with deficiency of Qi and Yin syndrome. Methods: From January 2016 to May 2017, 60 patients of stage IV DKD with deficiency of Qi and Yin syndrome who were recruited to be treated in the Department of Nephrology, Zhangjiagang Hospital of Traditional Chinese Medicine were randomly divided into a control group and a treatment group (30 cases of each) according to the random number table method. The control group received routine treatment, and the treatment group was treated with Erhuang Capsule benefit for Kidney on the basis of the control group, for 8 weeks. The laboratory examination indexes of the two groups before and after treatment were observed, and the data were evaluated from three aspects: disease efficacy, syndrome efficacy and renal function index efficacy. Results: In the improvement of laboratory parameters, the treatment group was more effective (P<0.05), and in terms of the disease efficacy evaluation, the treatment group was also significantly higher than the control group (P<0.05); but the effective rate between the groups was not Significant difference (P>0.05). Conclusion: Routine treatment combined with Erhuang Capsule benefit for Kidney can both effectively treat the stage IV of diabetic nephropathy with Qi and Yin deficiency; but treatment combined with Erhuang Capsule benefit for Kidney can significantly alleviate the patient’s condition and improve the clinical symptoms of patients, delay the deterioration of renal function.