文章摘要

上皮间质转化与肺非小细胞癌转移及其耐药性的研究进展

作者: 1谷蕴婷, 2张静
1 北京市朝阳区双桥医院病理科，北京 100024
2 北京协和医院病理科，北京 100010
通讯: 张静 Email: jingzhangsmile@163.com
DOI: 10.3978/j.issn.2095-6959.2018.09.031

摘要

上皮间质转化(epithelial-mesenchymal transition，EMT)是上皮细胞在多种因素作用下获得间质细胞表型的一种现象。在肺非小细胞癌(non-small cell lung cancer，NSCLC)中，EMT的发生促进非小细胞癌的侵袭转移，并诱导肿瘤细胞产生耐药性。本文拟对EMT在NSCLC转移及耐药过程中的重要作用做一综述，旨在找到NSCLC新的治疗策略。
关键词： 上皮间质转化；肺非小细胞癌；转移；耐药

Research progress of epithelial-mesenchymal transition with metastasis and drug-resistance in non-small cell lung cancer

Authors: 1GU Yunting, 2ZHANG Jing
1 Department of Pathology, Shuangqiao Hospital of Chaoyang District, Beijing 100024, China
2 Department of Pathology, Peking Union Medical College Hospital, Beijing 100010, China

CorrespondingAuthor: ZHANG Jing Email: jingzhangsmile@163.com

DOI: 10.3978/j.issn.2095-6959.2018.09.031

Abstract

Epithelial interstitial transformation (EMT) is a phenomenon in which epithelial cells get the phenotype of stromal cells under various factors. In non-small cell lung cancer (NSCLC), the occurrence of EMT promotes the invasion and metastasis of non-small cell carcinoma and induces the drug resistance of tumor cells. This article reviews the important role of EMT in NSCLC metastasis and drug resistance, in order to find a new treatment strategy for NSCLC.
Keywords： epithelial-mesenchymal transition; non-small cell lung cancer; metastasis; drug resistance

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