Objective: To describe the hope stress and quality of life in parents of very-low birth weight infants and investigate the determinants that can affect parental quality of life. Methods: Sixty VLBWI were borned in Dongtai Hospital Affiliated to Nantong University from January 2012 to June 2014 and their parents were selected as the experimental group, and 60 parents of healthy infants who borned at the same period were selected as control group. After 42 months from birth, all parents completed questionnaires about hope, parenting stress and quality of life, and to explore the factors that affect their quality of life. Results: The parental hope of very-low birth weight infants was significantly higher than that of healthy infants (P<0.05). Parental stress and quality of life were similar to those of healthy infants (P>0.05). Parental hope and parental stress were independent factors that affected the quality of life. Conclusion: The quality of life in parents of very-low birth weight infants is similar to that of healthy infants, and it is positively correlated with parental hope and negatively correlated with parental stress.