Objective: To explore the clinical effects of multiple re-education strategies on patients with stable chronic obstructive pulmonary disease (COPD) through re-educate patients with the usage of Symbicort mainly. Methods: A total of 105 patients were enrolled and randomly assigned into a control group and an observation group; all patients were treated with Symbicort for 6 months. The patients in the control group were demonstrated the usage of Symbicort by their attending physician when they leave hospital, on this foundation, the patients in the observation group were performed with re-education of the usage of Symbicort and health education and telephone follow-up based on the WeChat platform. After 6 months follow-up, we observed the medication compliance, the accuracy of the operation of inhalation device, whether hospitalization due to acute exacerbation of COPD, and the reexamination of the pulmonary function of two groups of patients. Results: The patients in the observation group were better than the control group in accuracy of the operation of Symbicort, index of lung function and medication compliance. The reentry hospital rates in the observation group was less than that in the control group within 6 months, the differences were both statistically significant (P<0.05). Conclusion: That re-education of the usage of inhalation medication device, health education and telephone follow-up, it can improve the standard and compliance of medication, delay the deterioration of the lung function more effectively, reduce the times of acute exacerbation of COPD of patients, so as to standardize the treatment of the stable phase of the COPD.