文章摘要

增殖性糖尿病视网膜病变对2型糖尿病患者无症状冠状动脉粥样硬化性心脏病的识别

作者: 1陆长峰, 2周建博
1 首都医科大学附属北京同仁医院神经内科,北京 100730
2 首都医科大学附属北京同仁医院内分泌科,北京 100730
通讯: 周建博 Email: Jianbo.zhou@foxmail.com
DOI: 10.3978/j.issn.2095-6959.2018.08.019
基金: 北京市医院管理局青苗人才项目(QML20170204)。

摘要

目的:探讨增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)对于无症状冠状动脉粥样硬化性心脏病(coronary atheroslerotic heart disease,CHD)的早期识别作用。方法:从北京同仁医院内分泌科选取351例2型糖尿病(T2 diabetes mellitus,T2DM)患者,其中211例非糖尿病视网膜病变(non-diabetic retinopathy,NDR)和140例PDR。受试者均无已知CHD,通过冠状动脉造影或冠状动脉CT诊断无症状性CHD。应用受试者工作特征曲线(receiver operating characteristic curve,ROC)和再分类指数评估PDR对无症状CHD的识别价值。结果:基于英国糖尿病前瞻性研究(United Kingdom Prospective Diabetes Study,UKPDS)模型,不合并PDR与合并PDR对无症状CHD的风险识别的曲线下面积(area under curve,AUC),从0.583 (95% CI:0.51~0.66)提高到0.697 (95% CI:0.641~0.752)。加入PDR后,对无症状CHD基本模型(8个传统的危险因素)识别的C统计值从0.746 (95% CI:0.681~0.811)增加到0.762 (95% CI:0.699~0.825,P=0.73),净重新分类指数(net reclassification indexes,NRI)为5.9% (95% CI:1.4%~10.2%,P=0.017),绝对综合判别指数(integrated discrimination index,IDI)为0.004 (P=0.02)。结论:与传统危险因素相比,PDR有助于识别T2DM患者的无症状CHD。
关键词: 增殖型糖尿病视网膜病变;无症状冠状动脉粥样硬化性心脏病;2型糖尿病

Identification of proliferative diabetic retinopathy to asymptomatic coronary heart disease in type 2 diabetes mellitus individuals

Authors: 1LU Changfeng, 2ZHOU Jianbo
1 Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2 Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

CorrespondingAuthor: ZHOU Jianbo Email: Jianbo.zhou@foxmail.com

DOI: 10.3978/j.issn.2095-6959.2018.08.019

Foundation: This work was supported by the Beijing Municipal Administration of Hospital’s Youth Project, China (QML20170204).

Abstract

Objective: To investigate the early identification of proliferative diabetic retinopathy (PDR) to coronary atheroslerotic heart disease (CHD). Methods: A total of 351 patients with type 2 diabetes mellitus (T2DM) individuals [211 non-diabetic retinopathy (NDR) and 140 proliferative diabetes mellitus (PDR)] were recruited from one of the national diabetes mellitus center from China. CHD was newly diagnosed and defined by the evidences of coronary angiography or computed tomography coronary angiography. The area under curve (AUC) was performed. Discrimination and reclassification were also used to evaluate the value of addition of PDR to the base model. Results: In our present study, with the model estimating risk of asymptomatic CHD based on the United Kingdom Prospective Diabetes Study (UKPDS) engine, we found that the level of AUC was greatly improved from 0.583 (95% CI: 0.51–0.66) to 0.697 (95% CI: 0.641–0.752) between the models with PDR and without PDR. Besides, the C statistic was increased from 0.746 (95% CI: 0.681–0.811) to 0.762 (95% CI: 0.699–0.825; P=0.73) by the addition of PDR to a base model to identify asymptomatic CHD. There was a continuous net reclassification indexes (NRI) of 5.9% (95% CI: 1.4%–10.2%, P=0.017) for the asymptomatic CHD. The absolute integrated discrimination index (IDI) was 0.004 (P=0.02). Conclusion: Compared with the traditional risk factors, our results improved the identification of asymptomatic CHD, which further confirmed that PDR could identify cardiovascular risk stratification in Chinese diabetic individuals.
Keywords: proliferative diabetic retinopathy; asymptomatic coronary heart disease; type 2 diabetes mellitus

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