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增殖性糖尿病视网膜病变对2型糖尿病患者无症状冠状动脉粥样硬化性心脏病的识别

  
@article{LCBL26698,
	author = {长峰 陆 和 建博 周},
	title = {增殖性糖尿病视网膜病变对2型糖尿病患者无症状冠状动脉粥样硬化性心脏病的识别},
	journal = {临床与病理杂志},
	volume = {38},
	number = {8},
	year = {2018},
	keywords = {},
	abstract = {目的:探讨增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)对于无症状冠状动脉粥样硬化性心脏病(coronary atheroslerotic heart disease,CHD)的早期识别作用。方法:从北京同仁医院内分泌科选取351例2型糖尿病(T2 diabetes mellitus,T2DM)患者,其中211例非糖尿病视网膜病变(non-diabetic retinopathy,NDR)和140例PDR。受试者均无已知CHD,通过冠状动脉造影或冠状动脉CT诊断无症状性CHD。应用受试者工作特征曲线(receiver operating characteristic curve,ROC)和再分类指数评估PDR对无症状CHD的识别价值。结果:基于英国糖尿病前瞻性研究(United Kingdom Prospective Diabetes Study,UKPDS)模型,不合并PDR与合并PDR对无症状CHD的风险识别的曲线下面积(area under curve,AUC),从0.583 (95% CI:0.51~0.66)提高到0.697 (95% CI:0.641~0.752)。加入PDR后,对无症状CHD基本模型(8个传统的危险因素)识别的C统计值从0.746 (95% CI:0.681~0.811)增加到0.762 (95% CI:0.699~0.825,P=0.73),净重新分类指数(net reclassification indexes,NRI)为5.9% (95% CI:1.4%~10.2%,P=0.017),绝对综合判别指数(integrated discrimination index,IDI)为0.004 (P=0.02)。结论:与传统危险因素相比,PDR有助于识别T2DM患者的无症状CHD。},
	url = {https://lcbl.amegroups.com/article/view/26698}
}