Objective: To determine the clinicopathological features, diagnosis, differential diagnosis, and clinical prognosis of gastrointestinal schwannoma. Methods: A retrospective study on 15 cases of neurilemmoma of the digestive tract was carried out. The clinical images, histopathology and immunohistochemical phenotypes were analyzed. The patients and the related literature were reviewed. Results: Among the 15 patients, there were 6 males and 9 females, aged 31–66 years old, with a median age of 51 years. Common site was the body of the stomach. The cells were composed of spindle cells, and the interstitial cells were infiltrated in different degrees. The boundaries of the surrounding tissues were clear, and the lymphocytic bands were found. Some of the lymphoid follicles could be formed. Immunohistochemistry showed all positive for S-100 and gial fibrillary acidic protein (GFAP) was be expressed in some cases. Follow-up for 12–90 months showed good prognosis, no recurrence, and metastasis. Conclusion: The schwannoma of the digestive tract is rare and is composed of diffuse spindle cells. It is difficult to distinguish between the histologic morphology and the gastrointestinal stromal tumor, but it is characterized by its histologic and immunohistochemical phenotypes.