Gankyrin 在结直肠癌和腺瘤中的表达及其临床意义
| 作者: |
1刘颖
1 河南科技大学附属三门峡市中心医院病理科，河南 三门峡 472000 |
| 通讯: |
刘颖
Email: liuyingsanmenxia@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.07.008 |
摘要
目的：探讨癌性锚蛋白重复序列(Gan n anky r i n repeat s ，Ganky r i n)在结直肠癌(col o rec t a l carcinoma，CRC)和腺瘤组织中的表达及其临床意义。方法：采用免疫组织化学检测Gankyrin在 94例CRC和87例腺瘤组织中的表达，同时分析Gankyrin表达与CRC临床病理学特征的相关性。 结果：Gankyrin在正常肠黏膜、腺瘤和CRC中的表达率分别为11.7%(11/94)，47.1%(41/87)， 70.2%(66/94，P<0.001)。Gankyrin在CRC中的表达与组织学分级、临床分期和转移相关(P<0.05)， 和患者性别、年龄以及肿瘤大小没有相关性(P>0.05)。结论：Gankyrin不仅参与CRC的早期发生， 也与CRC的恶性进展有关，有望成为CRC诊断和防治的靶标。
关键词：
癌性锚蛋白重复序列；结肠；直肠；癌；腺瘤
Department of Pathology, Central Hospital of Sanmenxia, Affiliated to Henan University of Science and Technology, Sanmenxia Henan 472000, China
CorrespondingAuthor: LIU Ying Email: liuyingsanmenxia@163.com
DOI: 10.3978/j.issn.2095-6959.2018.07.008
Abstract
Objective: To investigate the expression of Gann ankyrin repeats (Gankyrin) in colorectal carcinoma (CRC) and adenoma and its clinical significance. Methods: Immunohistochemical assay was performed to detect the expression of Gankyrin in 94 cases of CRCs and 87 cases of adenomas. In addition, the relationship between the expression of Gankyrin and the clinicopathological features of patients with CRCs was analyzed. Results: The rates of Gankyrin expression in normal intestinal mucosa, adenomas and CRCs were 11.7% (11/94), 47.1% (41/87), 70.2% (66/94), respectively (P<0.001). The expression of Gankyrin in CRCs was remarkably related with histologic grade of CRCs, metastasis, and the clinical stage (P<0.05). There was no correlation between the expression of Gankyrin and age, gender of patients with CRCs, size of tumors (P>0.05). Conclusion: Gankyrin does not only participate in the early carcinogenesis of CRCs, but also is related to their malignant progression. Gankyrin is a potential target for the diagnosis, prevention and treatment of CRCs.
Keywords：
Gann ankyrin repeats; colon; rectum; carcinoma; adenoma