Objective: To investigate the level of self-perceived burden among young and middle-aged patients after total hip arthroplasty and to analyze the influencing factors. Methods: One hundred and twelve patients with total hip arthroplasty were selected by convenient sampling. Then Self-Perception Burden Scale (SPBS) was used to investigate the results and PASW statistics 18.0 software was applied to analyze the results. Results: The score of self-perceived burden of the young and middle-aged patients after total hip arthroplasty was 34.60±8.78. There were 35 patients with severe stress (31.2%), 43 with moderate burden (38.4%), 29 with mild burden (25.9%), and 5 with less obvious burden (4.5%); factors such as education level, rehabilitation time after the operation, Harris hip function and the effect of medical expenses on family all influenced the self-feeling burden of patients, which explained 52.1% of variance. Conclusion: The self-perceived burden of the young and middle-aged patients after total hip arthroplasty is relatively heavy. It is necessary for nurses to carry out targeted nursing based on specific situation of the patients in order to reduce the adverse effects on the patients’ feelings.