血管生成素样蛋白3在肾病综合征中的研究进展
| 作者: |
1李鑫,
1吕慧妍,
1郝丽荣
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150070 |
| 通讯: |
郝丽荣
Email: hao_lirong@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.05.033 |
摘要
血管生成素样蛋白3(angiopoietin-like-3，ANGPTL3)是一种分泌蛋白，是血管生成素样蛋白家族的成员。ANGPTL3主要表达于肝，肾仅有少量表达。肾病综合征(nephrotic syndrome，NS)是以大量蛋白尿(>3.5 g/d)、低白蛋白血症(<30 g/L)、水肿及高脂血症为特点的临床综合征，可表现为各种病理类型。近期研究发现肾ANGPTL3表达异常与NS的常见病变足细胞损伤和蛋白尿相关，并参与NS高脂血症的调节。
关键词：
血管生成素样蛋白3；肾病综合征；足细胞；高脂血症
Research progress of angiopoietin-like-3 in nephrotic syndrome
CorrespondingAuthor: HAO Lirong Email: hao_lirong@163.com
DOI: 10.3978/j.issn.2095-6959.2018.05.033
Abstract
Angiopoietin-like-3 (ANGPTL3) is a secreted protein with a characteristic angiopoietin structure and it belongs to ANGPTL protein family. ANGPTL3 is mainly expressed in hepatocytes and only weakly expressed in normal kidney cell. Nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria (>3.5 g/d), hypoalbuminemia (<30 g/L), edema and hyperlipidemia. NS can involve various pathological types of kidney disease. Recent studies have found that the abnormal expression of ANGPTL3 in kidney is related to podocyte injury and proteinuria in NS, and is involved in the regulation of hyperlipidemia in NS.
Keywords：
angiopoietin-like-3; nephrotic syndrome; podocyte; hyperlipidemia