膀胱癌动物模型的建立方法对比及成瘤监测技术的进展
| 作者: |
1佟业飞,
1修有成,
1刘赞
1 哈尔滨医科大学附属第一医院泌尿外科三科，哈尔滨 150001 |
| 通讯: |
修有成
Email: 694484688@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.05.030 |
摘要
膀胱肿瘤是泌尿系统最常见的肿瘤，且治疗后容易复发和进展，因此迫切需要治疗膀胱肿瘤的新方法。无论是研究新治疗方法还是开展个体化治疗，都有赖于膀胱癌动物模型的成功建立。迄今为止，膀胱癌的动物模型建立方法很多且各有特点。建模成瘤后肿瘤的监测技术，特别是活体动态监测技术尤为重要。现将目前膀胱肿癌动物模型的建立和监测方法方面的进展进行综述，并讨论各种建立方法的优缺点，帮助研究者选择出最适合其实验的建模方案与监测技术。
关键词：
膀胱肿瘤；疾病模型；动物；肿瘤监测
Comparison of the methods of animal models of bladder cancer and the development of tumor monitoring techniques
CorrespondingAuthor: XIU Youcheng Email: 694484688@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.05.030
Abstract
Bladder tumor is the most common tumor in the urinary system, and is easy to relapse and progress after treatment. Therefore, there is an urgent need for new treatment of bladder tumor. Both the new treatment and individualized treatment depend on the success of the animal model of bladder cancer. Up to now, the animal model of bladder cancer has been established with many methods and characteristics. It is very important to monitor the tumor after the animal model is completed, especially in vivo dynamic monitoring. Now, I reviewed the progress in the establishment and monitoring of the current animal model of bladder tumor and discussed the advantages and disadvantages of various methods that to help researchers select the most suitable modeling scheme and monitoring technology.
Keywords：
bladder tumor; disease model; animal; tumor monitoring